{"id":{"repo_id":"york","oai_identifier":"oai:yorkspace.library.yorku.ca:10315/34502"},"canonical_url":"https://search.dev.ndltd.org/etd/york/oai:yorkspace.library.yorku.ca:10315/34502","repository":{"repo_id":"york","name":"York University","base_url":"https://yorkspace.library.yorku.ca/oai/request"},"display":{"title":"Development of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes","abstract":"Multi-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing a two-loop heart-cut strategy is reported. The system is capable of re-circulating effluents from each dimension through a single detector and performing heart-cut operations using a programmable ten-port, two-position heart-cut valve. The first dimension of analysis measures peak ratios of products to reagents while the second dimension offers peak purity of the heart-cut material. The third dimension uses a chiral column to measure the enantiomeric excess (ee) of the chiral analyte and the effluent from the third dimension is re-analyzed via a fourth dimension to determine if any loss of chirality has occurred resulting from the analytical method itself. Performance of the setup was evaluated using the synthesis of Warfarin as a model chemical process.","abstract_html":"Multi-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing a two-loop heart-cut strategy is reported. The system is capable of re-circulating effluents from each dimension through a single detector and performing heart-cut operations using a programmable ten-port, two-position heart-cut valve. The first dimension of analysis measures peak ratios of products to reagents while the second dimension offers peak purity of the heart-cut material. The third dimension uses a chiral column to measure the enantiomeric excess (ee) of the chiral analyte and the effluent from the third dimension is re-analyzed via a fourth dimension to determine if any loss of chirality has occurred resulting from the analytical method itself. Performance of the setup was evaluated using the synthesis of Warfarin as a model chemical process.","abstract_has_math":false,"creators":["Bizzari, Nour Majid"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Organ, Michael G.","Pietro, William"],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-05-28","date_published":"2018-05-28","updated_at":"2026-07-24T06:33:55Z","subjects":["Organic chemistry"],"languages":["en"],"rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10315/34502","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Organ, Michael G.","Pietro, William"]},{"key":"dc:creator","label":"Author","values":["Bizzari, Nour Majid"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-28T12:47:59Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-28T12:47:59Z"]},{"key":"dc:date.issued","label":"Date","values":["2018-05-28"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organic chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Author owns copyright, except where explicitly noted. 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The third dimension uses a chiral column to measure the enantiomeric excess (ee) of the chiral analyte and the effluent from the third dimension is re-analyzed via a fourth dimension to determine if any loss of chirality has occurred resulting from the analytical method itself. Performance of the setup was evaluated using the synthesis of Warfarin as a model chemical process."]},{"key":"dc:title","label":"Title","values":["Development of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Organ, Michael G.","Pietro, William"],"dc:creator":["Bizzari, Nour Majid"],"dc:date.accessioned":["2018-05-28T12:47:59Z"],"dc:date.available":["2018-05-28T12:47:59Z"],"dc:date.issued":["2018-05-28"],"dc:description.abstract":["Multi-dimensional HPLC techniques enable researchers to monitor multiple essential and sometimes, critical quality attributes (CQAs) in parallel. A unique three-column, four-dimension liquid chromatography system employing a two-loop heart-cut strategy is reported. The system is capable of re-circulating effluents from each dimension through a single detector and performing heart-cut operations using a programmable ten-port, two-position heart-cut valve. The first dimension of analysis measures peak ratios of products to reagents while the second dimension offers peak purity of the heart-cut material. The third dimension uses a chiral column to measure the enantiomeric excess (ee) of the chiral analyte and the effluent from the third dimension is re-analyzed via a fourth dimension to determine if any loss of chirality has occurred resulting from the analytical method itself. Performance of the setup was evaluated using the synthesis of Warfarin as a model chemical process."],"dc:identifier.uri":["http://hdl.handle.net/10315/34502"],"dc:language.iso":["en"],"dc:rights":["Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests."],"dc:subject":["Organic chemistry"],"dc:title":["Development of an Intelligent Heart-Cut Liquid Chromatography System for Chiral Analysis of Chemical Processes"],"dc:type":["Electronic Thesis or Dissertation"]},"updated_at":"2026-07-24T06:33:55Z"}