Abstract
Peri-operative care providers have a myriad of medication options when developing and implementing a plan for the management of post-operative nausea and vomiting (PONV). However, the provider must be aware of the potential side effects, complications, and interactions of those medications, especially when managing high-risk populations. While a peri-operative antiemetic algorithm exists for the management of PONV in the general population,1 an evidence-based antiemetic tool has not been developed for patient populations at risk for prolonged QT interval or patients who are routinely taking neurotransmitter modulating medications. Safe practice recommendations exist but are scattered throughout the literature. The goal of this project was to develop a tool for care providers that concatenates the evidence and provides safe practice guidelines in the selected populations. The aims for developing this tool were to perform a thorough literature search to gather evidence-based guidelines, to develop the tool, and then consult an expert panel for feedback and tool validation. The end result is a quickly accessible clinical tool for peri-operative care providers involved in PONV management.
","abstract_html":"<p>Abstract</p> <p>Peri-operative care providers have a myriad of medication options when developing and implementing a plan for the management of post-operative nausea and vomiting (PONV). However, the provider must be aware of the potential side effects, complications, and interactions of those medications, especially when managing high-risk populations. While a peri-operative antiemetic algorithm exists for the management of PONV in the general population,1 an evidence-based antiemetic tool has not been developed for patient populations at risk for prolonged QT interval or patients who are routinely taking neurotransmitter modulating medications. Safe practice recommendations exist but are scattered throughout the literature. The goal of this project was to develop a tool for care providers that concatenates the evidence and provides safe practice guidelines in the selected populations. The aims for developing this tool were to perform a thorough literature search to gather evidence-based guidelines, to develop the tool, and then consult an expert panel for feedback and tool validation. The end result is a quickly accessible clinical tool for peri-operative care providers involved in PONV management.</p>","abstract_has_math":false,"creators":["Hymel, Nicole Danielle Mancini"],"institution":null,"degree_name":"Doctor of Nursing Practice (DNP)","degree_level":"Open Access Thesis","degree_discipline":"Yale University School of Nursing","degree_department":null,"school":null,"contributors":["Marianne Davies","Chuck Biddle"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-01-01T08:00:00Z","date_published":"2019-01-01T08:00:00Z","updated_at":"2026-07-24T06:16:14Z","subjects":["Antiemetics","Drug interactions","Neurotransmitter modulating medications/agents","PONV","QT prolongation"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://elischolar.library.yale.edu/ysndt/1102","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Marianne Davies","Chuck Biddle"]},{"key":"dc:creator","label":"Author","values":["Hymel, Nicole Danielle Mancini"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Yale University School of Nursing"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Open Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Nursing Practice (DNP)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Antiemetics","Drug interactions","Neurotransmitter modulating medications/agents","PONV","QT prolongation"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://elischolar.library.yale.edu/ysndt/1102"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Abstract
Peri-operative care providers have a myriad of medication options when developing and implementing a plan for the management of post-operative nausea and vomiting (PONV). However, the provider must be aware of the potential side effects, complications, and interactions of those medications, especially when managing high-risk populations. While a peri-operative antiemetic algorithm exists for the management of PONV in the general population,1 an evidence-based antiemetic tool has not been developed for patient populations at risk for prolonged QT interval or patients who are routinely taking neurotransmitter modulating medications. Safe practice recommendations exist but are scattered throughout the literature. The goal of this project was to develop a tool for care providers that concatenates the evidence and provides safe practice guidelines in the selected populations. The aims for developing this tool were to perform a thorough literature search to gather evidence-based guidelines, to develop the tool, and then consult an expert panel for feedback and tool validation. The end result is a quickly accessible clinical tool for peri-operative care providers involved in PONV management.
"]},{"key":"dc:title","label":"Title","values":["The Development Of An Evidence-Based Anti-Emetic Tool For The Management Of Post-Operative Nausea And Vomiting In Patients At High Risk For Qt Prolongation And Patients Taking Neurotransmitter Modulating Medications"]}]}],"canonical_facts":{"dc:contributor":["Marianne Davies","Chuck Biddle"],"dc:creator":["Hymel, Nicole Danielle Mancini"],"dc:description.abstract":["Abstract
Peri-operative care providers have a myriad of medication options when developing and implementing a plan for the management of post-operative nausea and vomiting (PONV). However, the provider must be aware of the potential side effects, complications, and interactions of those medications, especially when managing high-risk populations. While a peri-operative antiemetic algorithm exists for the management of PONV in the general population,1 an evidence-based antiemetic tool has not been developed for patient populations at risk for prolonged QT interval or patients who are routinely taking neurotransmitter modulating medications. Safe practice recommendations exist but are scattered throughout the literature. The goal of this project was to develop a tool for care providers that concatenates the evidence and provides safe practice guidelines in the selected populations. The aims for developing this tool were to perform a thorough literature search to gather evidence-based guidelines, to develop the tool, and then consult an expert panel for feedback and tool validation. The end result is a quickly accessible clinical tool for peri-operative care providers involved in PONV management.
"],"dc:identifier":["https://elischolar.library.yale.edu/ysndt/1102"],"dc:subject":["Antiemetics","Drug interactions","Neurotransmitter modulating medications/agents","PONV","QT prolongation"],"dc:title":["The Development Of An Evidence-Based Anti-Emetic Tool For The Management Of Post-Operative Nausea And Vomiting In Patients At High Risk For Qt Prolongation And Patients Taking Neurotransmitter Modulating Medications"],"thesis:degree_discipline":["Yale University School of Nursing"],"thesis:degree_level":["Open Access Thesis"],"thesis:degree_name":["Doctor of Nursing Practice (DNP)"]},"updated_at":"2026-07-24T06:16:14Z"}