This prospective, descriptive study was designed to explore the baseline cardiovascular disease (CVD) risk factors of women newly diagnosed with breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline cardiovascular risk through the use of the Framingham General Cardiovascular Risk Assessment Score (FGCVRAS) calculation and heart/vascular age calculation. Subjects included 30 women (mean age 49.97). Mean FGCVRAS was 5.58% (SD 5.68), and mean heart/vascular age was 49.62 years (SD 18.33) with 9 women having heart/vascular ages that exceeded their actual ages. At a cardiovascular risk of approximately 5.3%, vascular age began to exceed actual age. At baseline, only 3 of the 30 women had ever had a cardiovascular risk assessment, 14 women had at least two CVD risk factors, and 6 women met diagnostic criteria for metabolic syndrome. Multiple regression showed that HDL, glucose, waist circumference, and mean systolic blood pressure most contributed to CVD risk as calculated by the FGCVRAS. At baseline, women diagnosed with breast cancer demonstrate a significant risk burden for CVD that needs to be assessed and addressed prior to beginning potentially cardiotoxic treatments.
","abstract_html":"<p>This prospective, descriptive study was designed to explore the baseline cardiovascular disease (CVD) risk factors of women newly diagnosed with breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline cardiovascular risk through the use of the Framingham General Cardiovascular Risk Assessment Score (FGCVRAS) calculation and heart/vascular age calculation. Subjects included 30 women (mean age 49.97). Mean FGCVRAS was 5.58% (SD 5.68), and mean heart/vascular age was 49.62 years (SD 18.33) with 9 women having heart/vascular ages that exceeded their actual ages. At a cardiovascular risk of approximately 5.3%, vascular age began to exceed actual age. At baseline, only 3 of the 30 women had ever had a cardiovascular risk assessment, 14 women had at least two CVD risk factors, and 6 women met diagnostic criteria for metabolic syndrome. Multiple regression showed that HDL, glucose, waist circumference, and mean systolic blood pressure most contributed to CVD risk as calculated by the FGCVRAS. At baseline, women diagnosed with breast cancer demonstrate a significant risk burden for CVD that needs to be assessed and addressed prior to beginning potentially cardiotoxic treatments.</p>","abstract_has_math":false,"creators":["Smith, Ashleigh Kristina"],"institution":null,"degree_name":"Master of Science in Nursing (MSN)","degree_level":"Open Access Thesis","degree_discipline":"Yale University School of Nursing","degree_department":null,"school":null,"contributors":["Jessica S. Coviello"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-01-01T08:00:00Z","date_published":"2012-01-01T08:00:00Z","updated_at":"2026-07-24T06:16:00Z","subjects":["Adult Advanced Practice Nursing, Breast cancer, Cardiovascular disease, Cardiovascular risk"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://elischolar.library.yale.edu/ysndt/1014","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jessica S. Coviello"]},{"key":"dc:creator","label":"Author","values":["Smith, Ashleigh Kristina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Yale University School of Nursing"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Open Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Nursing (MSN)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Adult Advanced Practice Nursing, Breast cancer, Cardiovascular disease, Cardiovascular risk"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://elischolar.library.yale.edu/ysndt/1014"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This prospective, descriptive study was designed to explore the baseline cardiovascular disease (CVD) risk factors of women newly diagnosed with breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline cardiovascular risk through the use of the Framingham General Cardiovascular Risk Assessment Score (FGCVRAS) calculation and heart/vascular age calculation. Subjects included 30 women (mean age 49.97). Mean FGCVRAS was 5.58% (SD 5.68), and mean heart/vascular age was 49.62 years (SD 18.33) with 9 women having heart/vascular ages that exceeded their actual ages. At a cardiovascular risk of approximately 5.3%, vascular age began to exceed actual age. At baseline, only 3 of the 30 women had ever had a cardiovascular risk assessment, 14 women had at least two CVD risk factors, and 6 women met diagnostic criteria for metabolic syndrome. Multiple regression showed that HDL, glucose, waist circumference, and mean systolic blood pressure most contributed to CVD risk as calculated by the FGCVRAS. At baseline, women diagnosed with breast cancer demonstrate a significant risk burden for CVD that needs to be assessed and addressed prior to beginning potentially cardiotoxic treatments.
"]},{"key":"dc:title","label":"Title","values":["Assessing Cardiovascular Disease Risk In Women Newly Diagnosed With Breast Cancer"]}]}],"canonical_facts":{"dc:contributor":["Jessica S. Coviello"],"dc:creator":["Smith, Ashleigh Kristina"],"dc:description.abstract":["This prospective, descriptive study was designed to explore the baseline cardiovascular disease (CVD) risk factors of women newly diagnosed with breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline cardiovascular risk through the use of the Framingham General Cardiovascular Risk Assessment Score (FGCVRAS) calculation and heart/vascular age calculation. Subjects included 30 women (mean age 49.97). Mean FGCVRAS was 5.58% (SD 5.68), and mean heart/vascular age was 49.62 years (SD 18.33) with 9 women having heart/vascular ages that exceeded their actual ages. At a cardiovascular risk of approximately 5.3%, vascular age began to exceed actual age. At baseline, only 3 of the 30 women had ever had a cardiovascular risk assessment, 14 women had at least two CVD risk factors, and 6 women met diagnostic criteria for metabolic syndrome. Multiple regression showed that HDL, glucose, waist circumference, and mean systolic blood pressure most contributed to CVD risk as calculated by the FGCVRAS. At baseline, women diagnosed with breast cancer demonstrate a significant risk burden for CVD that needs to be assessed and addressed prior to beginning potentially cardiotoxic treatments.
"],"dc:identifier":["https://elischolar.library.yale.edu/ysndt/1014"],"dc:subject":["Adult Advanced Practice Nursing, Breast cancer, Cardiovascular disease, Cardiovascular risk"],"dc:title":["Assessing Cardiovascular Disease Risk In Women Newly Diagnosed With Breast Cancer"],"thesis:degree_discipline":["Yale University School of Nursing"],"thesis:degree_level":["Open Access Thesis"],"thesis:degree_name":["Master of Science in Nursing (MSN)"]},"updated_at":"2026-07-24T06:16:00Z"}