Background: Endocrine therapy for breast cancer with Aromatase Inhibitors (AI) is designed to reduce risk of recurrence and improve survival. AI therapy is associated with a variety of symptoms including musculoskeletal complaints, which have contributed to discontinuation of treatment. It is significantly important to explore the symptom profile of AIs that contribute to patients' quality of life and adherence behavior. Objective: The purpose of the study was a secondary analysis exploring the symptom profile of post-menopausal breast cancer survivors on AIs. Methods: Data were collected from self-reported demographic and medical forms from 36 women on AIs identified in the primary study. Symptoms were identified using the Breast Cancer Prevention Trial Symptom Checklist (BCPT-SCL) and mean severity distress scores were calculated for each symptom. Results: The most frequently reported symptoms were musculoskeletal and vasomotor specifically joint pain (75%), hot flashes (75%), general aches and pains (75%), and muscle stiffness (69.4%). The highest reported mean severity distress score was unhappiness with body image. Conclusions: There is no confirmed etiology or established evidence based management for musculoskeletal complaints related to AI use. Future studies are needed to further understand AI-related musculoskeletal symptoms in order to develop interventions to improve symptom management and symptom distress.
","abstract_html":"<p>Background: Endocrine therapy for breast cancer with Aromatase Inhibitors (AI) is designed to reduce risk of recurrence and improve survival. AI therapy is associated with a variety of symptoms including musculoskeletal complaints, which have contributed to discontinuation of treatment. It is significantly important to explore the symptom profile of AIs that contribute to patients' quality of life and adherence behavior. Objective: The purpose of the study was a secondary analysis exploring the symptom profile of post-menopausal breast cancer survivors on AIs. Methods: Data were collected from self-reported demographic and medical forms from 36 women on AIs identified in the primary study. Symptoms were identified using the Breast Cancer Prevention Trial Symptom Checklist (BCPT-SCL) and mean severity distress scores were calculated for each symptom. Results: The most frequently reported symptoms were musculoskeletal and vasomotor specifically joint pain (75%), hot flashes (75%), general aches and pains (75%), and muscle stiffness (69.4%). The highest reported mean severity distress score was unhappiness with body image. Conclusions: There is no confirmed etiology or established evidence based management for musculoskeletal complaints related to AI use. Future studies are needed to further understand AI-related musculoskeletal symptoms in order to develop interventions to improve symptom management and symptom distress.</p>","abstract_has_math":false,"creators":["Cao, May"],"institution":null,"degree_name":"Master of Science in Nursing (MSN)","degree_level":"Open Access Thesis","degree_discipline":"Yale University School of Nursing","degree_department":null,"school":null,"contributors":["Tish Knobf"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-01-01T08:00:00Z","date_published":"2013-01-01T08:00:00Z","updated_at":"2026-07-24T06:16:00Z","subjects":["Aromatase inhibitors, Breast cancer, Breast Cancer Prevention Trial Symptom Checklist, Quality of life, Secondary analysis"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://elischolar.library.yale.edu/ysndt/1002","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tish Knobf"]},{"key":"dc:creator","label":"Author","values":["Cao, May"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Yale University School of Nursing"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Open Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Nursing (MSN)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aromatase inhibitors, Breast cancer, Breast Cancer Prevention Trial Symptom Checklist, Quality of life, Secondary analysis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://elischolar.library.yale.edu/ysndt/1002"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Endocrine therapy for breast cancer with Aromatase Inhibitors (AI) is designed to reduce risk of recurrence and improve survival. AI therapy is associated with a variety of symptoms including musculoskeletal complaints, which have contributed to discontinuation of treatment. It is significantly important to explore the symptom profile of AIs that contribute to patients' quality of life and adherence behavior. Objective: The purpose of the study was a secondary analysis exploring the symptom profile of post-menopausal breast cancer survivors on AIs. Methods: Data were collected from self-reported demographic and medical forms from 36 women on AIs identified in the primary study. Symptoms were identified using the Breast Cancer Prevention Trial Symptom Checklist (BCPT-SCL) and mean severity distress scores were calculated for each symptom. Results: The most frequently reported symptoms were musculoskeletal and vasomotor specifically joint pain (75%), hot flashes (75%), general aches and pains (75%), and muscle stiffness (69.4%). The highest reported mean severity distress score was unhappiness with body image. Conclusions: There is no confirmed etiology or established evidence based management for musculoskeletal complaints related to AI use. Future studies are needed to further understand AI-related musculoskeletal symptoms in order to develop interventions to improve symptom management and symptom distress.
"]},{"key":"dc:title","label":"Title","values":["Symptoms Experienced By Post-Menopausal Breast Cancer Survivors On Aromatase Inhibitors: A Secondary Analysis Of Baseline Data"]}]}],"canonical_facts":{"dc:contributor":["Tish Knobf"],"dc:creator":["Cao, May"],"dc:description.abstract":["Background: Endocrine therapy for breast cancer with Aromatase Inhibitors (AI) is designed to reduce risk of recurrence and improve survival. AI therapy is associated with a variety of symptoms including musculoskeletal complaints, which have contributed to discontinuation of treatment. It is significantly important to explore the symptom profile of AIs that contribute to patients' quality of life and adherence behavior. Objective: The purpose of the study was a secondary analysis exploring the symptom profile of post-menopausal breast cancer survivors on AIs. Methods: Data were collected from self-reported demographic and medical forms from 36 women on AIs identified in the primary study. Symptoms were identified using the Breast Cancer Prevention Trial Symptom Checklist (BCPT-SCL) and mean severity distress scores were calculated for each symptom. Results: The most frequently reported symptoms were musculoskeletal and vasomotor specifically joint pain (75%), hot flashes (75%), general aches and pains (75%), and muscle stiffness (69.4%). The highest reported mean severity distress score was unhappiness with body image. Conclusions: There is no confirmed etiology or established evidence based management for musculoskeletal complaints related to AI use. Future studies are needed to further understand AI-related musculoskeletal symptoms in order to develop interventions to improve symptom management and symptom distress.
"],"dc:identifier":["https://elischolar.library.yale.edu/ysndt/1002"],"dc:subject":["Aromatase inhibitors, Breast cancer, Breast Cancer Prevention Trial Symptom Checklist, Quality of life, Secondary analysis"],"dc:title":["Symptoms Experienced By Post-Menopausal Breast Cancer Survivors On Aromatase Inhibitors: A Secondary Analysis Of Baseline Data"],"thesis:degree_discipline":["Yale University School of Nursing"],"thesis:degree_level":["Open Access Thesis"],"thesis:degree_name":["Master of Science in Nursing (MSN)"]},"updated_at":"2026-07-24T06:16:00Z"}