{"id":{"repo_id":"wvu","oai_identifier":"oai:researchrepository.wvu.edu:etd-2511"},"canonical_url":"https://search.dev.ndltd.org/etd/wvu/oai:researchrepository.wvu.edu:etd-2511","repository":{"repo_id":"wvu","name":"West Virginia University","base_url":"https://researchrepository.wvu.edu/do/oai/"},"display":{"title":"Smoking and dose-dependent early effects of nicotine on bone mechanical properties and histology","abstract":"The objective was to study the effects of nicotine and cigarette smoke on mechanical properties of cortical bone. Experiments were conducted for 5 weeks with New Zealand White Rabbits. The first experiment of 18 rabbits studied the effect of nicotine levels delivered via a nicotine patch (5.25, 10.5, 21 ng/ml), measured by different mechanical tests, porosity, and composition. There was no significant difference between the control and the treatment groups.;The second experiment of 22 rabbits studied the effects of nicotine delivered via a nicotine patch (10.5 ng/ml) and via a smoking chamber on fracture toughness and porosity. The rabbits exposed to the smoke for 5 weeks had significantly lower fracture toughness values when compared to the different groups (exposed to smoke for 4 weeks group, nicotine group, and the control group). This suggests that other agents besides nicotine are responsible for the weakening of bone clinically seen in smokers.","abstract_html":"The objective was to study the effects of nicotine and cigarette smoke on mechanical properties of cortical bone. Experiments were conducted for 5 weeks with New Zealand White Rabbits. The first experiment of 18 rabbits studied the effect of nicotine levels delivered via a nicotine patch (5.25, 10.5, 21 ng/ml), measured by different mechanical tests, porosity, and composition. There was no significant difference between the control and the treatment groups.;The second experiment of 22 rabbits studied the effects of nicotine delivered via a nicotine patch (10.5 ng/ml) and via a smoking chamber on fracture toughness and porosity. The rabbits exposed to the smoke for 5 weeks had significantly lower fracture toughness values when compared to the different groups (exposed to smoke for 4 weeks group, nicotine group, and the control group). This suggests that other agents besides nicotine are responsible for the weakening of bone clinically seen in smokers.","abstract_has_math":false,"creators":["Porter, Daniel Shaw"],"institution":null,"degree_name":"MS","degree_level":"Thesis","degree_discipline":"Mechanical and Aerospace Engineering","degree_department":null,"school":null,"contributors":["Timothy Norman."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004-08-01T07:00:00Z","date_published":"2004-08-01T07:00:00Z","updated_at":"2026-07-24T06:15:47Z","subjects":["Mechanical engineering","Biomedical engineering","Toxicology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://researchrepository.wvu.edu/etd/1508"],"render_values":[{"text":"https://researchrepository.wvu.edu/etd/1508","href":"https://researchrepository.wvu.edu/etd/1508","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.33915/etd.1508","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Timothy Norman."]},{"key":"dc:creator","label":"Author","values":["Porter, Daniel Shaw"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2019-01-17T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical and Aerospace Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MS"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mechanical engineering","Biomedical engineering","Toxicology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.33915/etd.1508","https://researchrepository.wvu.edu/etd/1508"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The objective was to study the effects of nicotine and cigarette smoke on mechanical properties of cortical bone. Experiments were conducted for 5 weeks with New Zealand White Rabbits. The first experiment of 18 rabbits studied the effect of nicotine levels delivered via a nicotine patch (5.25, 10.5, 21 ng/ml), measured by different mechanical tests, porosity, and composition. There was no significant difference between the control and the treatment groups.;The second experiment of 22 rabbits studied the effects of nicotine delivered via a nicotine patch (10.5 ng/ml) and via a smoking chamber on fracture toughness and porosity. The rabbits exposed to the smoke for 5 weeks had significantly lower fracture toughness values when compared to the different groups (exposed to smoke for 4 weeks group, nicotine group, and the control group). This suggests that other agents besides nicotine are responsible for the weakening of bone clinically seen in smokers."]},{"key":"dc:title","label":"Title","values":["Smoking and dose-dependent early effects of nicotine on bone mechanical properties and histology"]}]}],"canonical_facts":{"dc:contributor":["Timothy Norman."],"dc:creator":["Porter, Daniel Shaw"],"dc:date.available":["2019-01-17T08:00:00Z"],"dc:description.abstract":["The objective was to study the effects of nicotine and cigarette smoke on mechanical properties of cortical bone. Experiments were conducted for 5 weeks with New Zealand White Rabbits. The first experiment of 18 rabbits studied the effect of nicotine levels delivered via a nicotine patch (5.25, 10.5, 21 ng/ml), measured by different mechanical tests, porosity, and composition. There was no significant difference between the control and the treatment groups.;The second experiment of 22 rabbits studied the effects of nicotine delivered via a nicotine patch (10.5 ng/ml) and via a smoking chamber on fracture toughness and porosity. The rabbits exposed to the smoke for 5 weeks had significantly lower fracture toughness values when compared to the different groups (exposed to smoke for 4 weeks group, nicotine group, and the control group). This suggests that other agents besides nicotine are responsible for the weakening of bone clinically seen in smokers."],"dc:identifier":["https://doi.org/10.33915/etd.1508","https://researchrepository.wvu.edu/etd/1508"],"dc:subject":["Mechanical engineering","Biomedical engineering","Toxicology"],"dc:title":["Smoking and dose-dependent early effects of nicotine on bone mechanical properties and histology"],"thesis:degree_discipline":["Mechanical and Aerospace Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["MS"]},"updated_at":"2026-07-24T06:15:47Z"}