Abstract
dc:description.abstract<p>Photoacoustic microscopy is a hybrid imaging modality with high spatial resolution, moderate imaging depth, excellent imaging contrast and functional imaging capability. Taking full advantage of this powerful weapon, we have investigated different anatomical, functional, flow dynamic and metabolic parameter measurements using photoacoustic microscopy. Specifically, Evans-blue dye was used to enhance photoacoustic microscopy of capillaries; label-free transverse and axial blood flow was measured based on bandwidth broadening and time shift of the photoacoustic signals; metabolic rate of oxygen was quantified <italic>in vivo</italic> from all the five parameters measured by photoacoustic microcopy; whole cross-sectional imaging of small intestine was achieved on a double-illumination photoacoustic microscopy with extended depth of focus and imaging depth; hemodynamic imaging was performed on a MEMS-mirror enhanced photoacoustic microscopy with a cross-sectional imaging rate of 400 Hz. As a maturing imaging technique, PAM is expected to find new applications in both fundamental life science and clinical practice.</p>
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Biomedical Engineering
- Year dc:date.available
- 2012
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Yao, Junjie
- Contributors dc:contributor
-
- Lihong V Wang
Subjects
dc:subject × 6Rights
- Language dc:language
- English (en)
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:openscholarship.wustl.edu:etd-2025