Dynamic Deformation and Mechanical Properties of Brain Tissue

<p>Traumatic brain injury is an important medical problem affecting millions of people. Mathematical models of brain biomechanics are being developed to simulate the mechanics of brain injury and to design protective devices. However, because of a lack of quantitative data on brain-skull boundary conditions and deformations, the predictions of mathematical models remain uncertain. The objectives of this dissertation are to develop methods and obtain experimental data that will be used to parameterize and validate models of traumatic brain injury. To that end, this dissertation first addresses the brain-skull boundary conditions by measuring human brain motion using tagged magnetic resonance imaging. Magnetic resonance elastography was performed in the ferret brain to measure its mechanical properties in vivo. Brain tissue is not only heterogeneous, but may also be anisotropic. To characterize tissue anisotropy, an experimental procedure combining both shear testing and indentation was developed and applied to white matter and gray matter. These measurements of brain-skull interactions and mechanical properties of the brain will be valuable in the development and validation of finite element simulations of brain biomechanics.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Mechanical Engineering and Materials Science

Year dc:date.available

2012

Author dc:creator

• Feng, Yuan

Contributors dc:contributor

• Philip V Bayly

• brain tissue property
• image processing
• magnetic resonance imaging
• relative displacement
• transversely isotropic
• viscoleastic

Language dc:language

English (en)

DOI

https://doi.org/10.7936/K7DB7ZW9

OAI identifier oai:identifier

oai:openscholarship.wustl.edu:etd-2003