Washington University in St. Louis
A Graph-Based Algorithm to Determine Protein Structure from Cryo-EM Data
Abstract
dc:description.abstractCryo-electron microscopy: cryo-EM) provides 3D density maps of proteins, but these maps do not have sufficiently high resolution to directly yield atomic-scale models. Previous work has shown that features known as secondary structures can be located in these density maps. A second source of information about proteins is sequence analysis, which predicts locations of secondary structures along the protein sequence but does not provide any information about the 3D shape of the protein. This thesis presents a graph-based algorithm to find the correspondence between the secondary structures in the density map and sequence. This provides an ordering of secondary structures in the 3D density map, which can be used in building an atomic-scale model of the protein.
Degree
thesis:*- Name thesis:degree_name
- Master of Arts (MA)
- Level thesis:degree_level
- Thesis
- Discipline thesis:degree_discipline
- Computer Science and Engineering
- Year dc:date.available
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Schuh, Stephen
- Contributors dc:contributor
-
- Tao Ju
Subjects
dc:subject × 1Rights
- Language dc:language
- English (en)
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:openscholarship.wustl.edu:etd-1505