Advances in real-time thoracic guidance systems

Substantial tissue motion: >1cm) arises in the thoracic/abdominal cavity due to respiration. There are many clinical applications in which localizing tissue with high accuracy: <1mm) is important. Potential applications include radiation therapy, radio frequency ablation, lung/liver biopsies, and brachytherapy seed placement. Recent efforts have made highly accurate sub-mm 3D localization of discrete points available via electromagnetic: EM) position monitoring. Technology from Calypso Medical allows for simultaneous tracking of up to three implanted wireless transponders. Additionally, Medtronic Navigation uses wired electromagnetic tracking to guide surgical tools for image guided surgery: IGS). Utilizing real-time EM position monitoring, a prototype system was developed to guide a therapeutic linear accelerator to follow a moving target: tumor) within the lung/abdomen. In a clinical setting, electromagnetic transponders would be bronchoscopically implanted into the lung of the patient in or near the tumor. These transponders would ax to the lung tissue in a stable manner and allow real-time position knowledge throughout a course of radiation therapy. During each dose of radiation, the beam is either halted when the target is outside of a given threshold, or in a later study the beam follows the target in real-time based on the EM position monitoring. We present quantitative analysis of the accuracy and efficiency of the radiation therapy tumor tracking system. EM tracking shows promise for IGS applications. Tracking the position of the instrument tip allows for minimally invasive intervention and alleviates the trauma associated with conventional surgery. Current clinical IGS implementations are limited to static targets: e.g. craniospinal, neurological, and orthopedic intervention. We present work on the development of a respiratory correlated image guided surgery: RCIGS) system. In the RCIGS system, target positions are modeled via respiratory correlated imaging: 4DCT) coupled with a breathing surrogate representative of the patient's respiratory phase/amplitude. Once the target position is known with respect to the surrogate, intervention can be performed when the target is in the correct location. The RCIGS system consists of imaging techniques and custom developed software to give visual and auditory feedback to the surgeon indicating both the proper location and time for intervention. Presented here are the details of the IGS lung system along with quantitative results of the system accuracy in motion phantom, ex-vivo porcine lung, and human cadaver environments.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biomedical Engineering

Year dc:date.available

2011

Author dc:creator

• Smith, Ryan

Contributors dc:contributor

• Parag Parikh

• Biomedical Engineering
• Electrical Engineering
• electromagnetic tracknig
• image guided surgery
• lung
• minimally invasive
• motion management
• radiation oncology

Language dc:language

English (en)

DOI

https://doi.org/10.7936/K700003K

OAI identifier oai:identifier

oai:openscholarship.wustl.edu:etd-1326