Engineering Mussel Foot Protein 5 (MFP5) for Enhanced Adhesive Performance in Tendon and Bone Repair

<p>This study explores the development of Mussel Foot Protein 5 (MFP5) bioadhesives to improve tendon-to-tendon and tendon-to-bone adhesive outcomes. MFP5, known for its underwater adhesive properties, was synthesized using recombinant techniques and optimized through coacervation and cross-linking. Adhesion tests demonstrated the superior performance of the optimized MFP5 adhesive on the tendon and bone samples. Improved protein concentration testing and purification methods enhanced MFP5 yield and consistency. Future research will focus on further standardization, exploring alternative purification methods, and evaluating the adhesive's performance in animal models. This study lays a foundation for developing robust MFP5-based bioadhesives, potentially revolutionizing surgical repair techniques and enhancing tissue integration and healing.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Biomedical Engineering

Year dc:date.available

2024

Author dc:creator

• Zhu, Ziyue

Contributors dc:contributor

• Fuzhong Zhang
• Michael Vahey, Dennis Barbour

• Biochemical and Biomolecular Engineering
• Biomaterials

Statement dc:rights

• I have not registered my thesis with the U.S. Copyright Office, and do not intend to.

Language dc:language

English (en)

Identifier

https://openscholarship.wustl.edu/eng_etds/1066

OAI identifier oai:identifier

oai:openscholarship.wustl.edu:eng_etds-2131