{"id":{"repo_id":"wurz-thes","oai_identifier":"oai:opus.bibliothek.uni-wuerzburg.de:967"},"canonical_url":"https://search.dev.ndltd.org/etd/wurz-thes/oai:opus.bibliothek.uni-wuerzburg.de:967","repository":{"repo_id":"wurz-thes","name":"Universität Wüzburg","base_url":"https://opus.bibliothek.uni-wuerzburg.de/oai"},"display":{"title":"Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry","abstract":"The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. Studies on the biological activities of sila-venlafaxine and of silicon-based allosteric modulators of muscarinic receptors are discussed. The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is described as a novel, acid-labile protecting group in organosilicon chemistry. The synthesis of chlorotris(chloromethyl)silane and tris(chloromethyl)methoxysilane is described.","abstract_html":"The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. Studies on the biological activities of sila-venlafaxine and of silicon-based allosteric modulators of muscarinic receptors are discussed. The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is described as a novel, acid-labile protecting group in organosilicon chemistry. The synthesis of chlorotris(chloromethyl)silane and tris(chloromethyl)methoxysilane is described.","abstract_has_math":false,"creators":["Daiß, Jürgen Oliver"],"institution":"Universität Würzburg","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Tacke, Reinhold"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004-12-17","date_published":"2004-12-17","updated_at":"2026-07-24T06:11:30Z","subjects":["Silicium","Bioisosterie","Schutzgruppe","Venlafaxin","Bexaroten","Silicon","bioisosterism","protecting group","venlafaxine","bexarotene"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/967","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tacke, Reinhold"]},{"key":"dc:creator","label":"Author","values":["Daiß, Jürgen Oliver"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universität Würzburg"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Universität Würzburg"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Silicium","Bioisosterie","Schutzgruppe","Venlafaxin","Bexaroten","Silicon","bioisosterism","protecting group","venlafaxine","bexarotene"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. Studies on the biological activities of sila-venlafaxine and of silicon-based allosteric modulators of muscarinic receptors are discussed. The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is described as a novel, acid-labile protecting group in organosilicon chemistry. The synthesis of chlorotris(chloromethyl)silane and tris(chloromethyl)methoxysilane is described.","Die vorliegende Arbeit beschreibt die Synthese von Sila-Venlafaxin, Disila-Bexaroten, Disila-AG-045572 (Disila-CMPD1), einer Reihe allosterer Modulatoren von Muscarin-Rezeptoren auf Silicium-Basis sowie eine Teilsynthese von Sila-Gabapentin. Kristallstrukturdaten von rac-Sila-Venlafaxin Hydrochlorid, (R)-Sila-Venlafaxin Hydrobromid, Bexaroten, Disila-Bexaroten und Disila-AG-045572 (Disila-CMPD1) sind enthalten. Untersuchungen der biologischen Aktivität von Sila-Venlafaxin und allosterer Modulatoren von Muscarin-Rezeptoren auf Silicium-Basis werden diskutiert. Die Si-2,4,6-trimethoxyphenyl-Gruppe (Si-2,4,6-TMOP)wird als neuartige säurelabile Scutzgruppe für die Organosilicium-Chemie beschrieben. Die Synthese von Chlortris(chlormethyl)silan und Tris(chlormethyl)methoxysilan wird ebenfalls beschrieben."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry","Synthese von Sila-Analoga und siliciumhaltigen Derivaten von Wirkstoffen und Entwicklung und Anwendung der Si-2,4,6-Trimethoxyphenyl-Gruppe als neuartige Schutzgruppe in der Organosilicium-Chemie"]}]}],"canonical_facts":{"dc:contributor":["Tacke, Reinhold"],"dc:creator":["Daiß, Jürgen Oliver"],"dc:description.abstract":["The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. Studies on the biological activities of sila-venlafaxine and of silicon-based allosteric modulators of muscarinic receptors are discussed. The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is described as a novel, acid-labile protecting group in organosilicon chemistry. The synthesis of chlorotris(chloromethyl)silane and tris(chloromethyl)methoxysilane is described.","Die vorliegende Arbeit beschreibt die Synthese von Sila-Venlafaxin, Disila-Bexaroten, Disila-AG-045572 (Disila-CMPD1), einer Reihe allosterer Modulatoren von Muscarin-Rezeptoren auf Silicium-Basis sowie eine Teilsynthese von Sila-Gabapentin. Kristallstrukturdaten von rac-Sila-Venlafaxin Hydrochlorid, (R)-Sila-Venlafaxin Hydrobromid, Bexaroten, Disila-Bexaroten und Disila-AG-045572 (Disila-CMPD1) sind enthalten. Untersuchungen der biologischen Aktivität von Sila-Venlafaxin und allosterer Modulatoren von Muscarin-Rezeptoren auf Silicium-Basis werden diskutiert. Die Si-2,4,6-trimethoxyphenyl-Gruppe (Si-2,4,6-TMOP)wird als neuartige säurelabile Scutzgruppe für die Organosilicium-Chemie beschrieben. Die Synthese von Chlortris(chlormethyl)silan und Tris(chlormethyl)methoxysilan wird ebenfalls beschrieben."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universität Würzburg"],"dc:subject":["Silicium","Bioisosterie","Schutzgruppe","Venlafaxin","Bexaroten","Silicon","bioisosterism","protecting group","venlafaxine","bexarotene"],"dc:title":["Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry","Synthese von Sila-Analoga und siliciumhaltigen Derivaten von Wirkstoffen und Entwicklung und Anwendung der Si-2,4,6-Trimethoxyphenyl-Gruppe als neuartige Schutzgruppe in der Organosilicium-Chemie"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Universität Würzburg"]},"updated_at":"2026-07-24T06:11:30Z"}