Dendritic cells activated by CpG motifs are potent inducers of a Th1 immune response that protects mice against leishmaniasis

The present investigation report a protocol to obtain dendritic cells (DC) that protects mice against fatal leishmaniasis. DC were generated from bone marrow precursors, pulsed with leishmanial antigen and activated with CpG oligodeoxinucleotides. Mice that were vaccinated with these cells were strongly protected against the clinical and parasitological manifestations of leishmaniasis and developed a Th1 immune response. protection was solid and long-lasting, and was also dependent of the via of administration. Whe the mechanism of protection was studied, it was observed that the availability of the cytokine interleukin-12 at the time of vaccination was a key requirement, but that the source of this cytokine is not the donor cells but unidentified cells from the recipients.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Universität Würzburg

Year

2004

Author dc:creator

• Ramirez Pineda, José Robinson

Contributors dc:contributor

• Moll, Heidrun

• Dendrtitischer Zellen
• Th1 immunantwort
• leishmaniose
• CpG
• Dendritic cells
• Th1 response
• leishmaniasis

Repository record source_url

https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/732

OAI identifier oai:identifier

oai:opus.bibliothek.uni-wuerzburg.de:732