{"id":{"repo_id":"wurz-thes","oai_identifier":"oai:opus.bibliothek.uni-wuerzburg.de:530"},"canonical_url":"https://search.dev.ndltd.org/etd/wurz-thes/oai:opus.bibliothek.uni-wuerzburg.de:530","repository":{"repo_id":"wurz-thes","name":"Universität Wüzburg","base_url":"https://opus.bibliothek.uni-wuerzburg.de/oai"},"display":{"title":"Einfluss des Tyrosinkinaseninhibitors PTK 787/ZK 222584 auf Vaskularisation und Wachstum intracerebraler Gliome der Ratte","abstract":"Einfluss des VEGFRezeptor-2 spezifischen RTK-Inhibitors PTK 787/ ZK 222584 auf Angiogenese und somit Wachstum maligner Gliome in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender Zellklon generiert wurde.","abstract_html":"Einfluss des VEGFRezeptor-2 spezifischen RTK-Inhibitors PTK 787/ ZK 222584 auf Angiogenese und somit Wachstum maligner Gliome in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender Zellklon generiert wurde.","abstract_has_math":false,"creators":["Kiderlen, Michael"],"institution":"Universität Würzburg","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Goldbrunner, Roland"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2003,"date_issued":"2003-07-08","date_published":"2003-07-08","updated_at":"2026-07-24T06:11:16Z","subjects":["Gliom","Ratte","VEGF","Vaskularisation","C6-Zellen","glioma","rat","vascularisation","C6 cells"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/530","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Goldbrunner, Roland"]},{"key":"dc:creator","label":"Author","values":["Kiderlen, Michael"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universität Würzburg"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Universität Würzburg"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gliom","Ratte","VEGF","Vaskularisation","C6-Zellen","glioma","rat","vascularisation","C6 cells"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Einfluss des VEGFRezeptor-2 spezifischen RTK-Inhibitors PTK 787/ ZK 222584 auf Angiogenese und somit Wachstum maligner Gliome in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender Zellklon generiert wurde.","The influence of PTK 787/ ZK 222584 -a VEGFR 2 antagonist- shown in an animal modell. C6-Rat glioma cells where implanted into the cortex of Sprague-Dawley rats. After early or late treatment with PTK 787 all animals were monitored at post-implantation day 12 using MRI-Technology. Immunohistology was used to measure vascularisation- and proliferation index and apotosis rate."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Einfluss des Tyrosinkinaseninhibitors PTK 787/ZK 222584 auf Vaskularisation und Wachstum intracerebraler Gliome der Ratte","Influence of PTK 787/ZK 222584 concerning vascularisation and tumor growth of intracranial C6-rat tumors"]}]}],"canonical_facts":{"dc:contributor":["Goldbrunner, Roland"],"dc:creator":["Kiderlen, Michael"],"dc:description.abstract":["Einfluss des VEGFRezeptor-2 spezifischen RTK-Inhibitors PTK 787/ ZK 222584 auf Angiogenese und somit Wachstum maligner Gliome in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender Zellklon generiert wurde.","The influence of PTK 787/ ZK 222584 -a VEGFR 2 antagonist- shown in an animal modell. C6-Rat glioma cells where implanted into the cortex of Sprague-Dawley rats. After early or late treatment with PTK 787 all animals were monitored at post-implantation day 12 using MRI-Technology. Immunohistology was used to measure vascularisation- and proliferation index and apotosis rate."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universität Würzburg"],"dc:subject":["Gliom","Ratte","VEGF","Vaskularisation","C6-Zellen","glioma","rat","vascularisation","C6 cells"],"dc:title":["Einfluss des Tyrosinkinaseninhibitors PTK 787/ZK 222584 auf Vaskularisation und Wachstum intracerebraler Gliome der Ratte","Influence of PTK 787/ZK 222584 concerning vascularisation and tumor growth of intracranial C6-rat tumors"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Universität Würzburg"]},"updated_at":"2026-07-24T06:11:16Z"}