{"id":{"repo_id":"wurz-thes","oai_identifier":"oai:opus.bibliothek.uni-wuerzburg.de:395"},"canonical_url":"https://search.dev.ndltd.org/etd/wurz-thes/oai:opus.bibliothek.uni-wuerzburg.de:395","repository":{"repo_id":"wurz-thes","name":"Universität Wüzburg","base_url":"https://opus.bibliothek.uni-wuerzburg.de/oai"},"display":{"title":"Studien zur C/Si-Bioisosterie","abstract":"Im Rahmen der vorliegenden Arbeit wurden Beiträge zur C/Si-Bioisosterie und zur asymmetrischen Synthese neuer siliciumhaltiger alpha-Aminosäuren geleistet. Im Vordergrund der Untersuchungen stand die Entwicklung neuer präparativer Methoden zur Darstellung siliciumhaltiger Wirkstoffe und die Untersuchung ihrer pharmakologischen Wirksamkeit sowie die Synthese racemischer und enantiomerenreiner siliciumhaltiger alpha-Aminosäuren des beta-(Trimethylsilyl)alanin-Typs.","abstract_html":"Im Rahmen der vorliegenden Arbeit wurden Beiträge zur C/Si-Bioisosterie und zur asymmetrischen Synthese neuer siliciumhaltiger alpha-Aminosäuren geleistet. Im Vordergrund der Untersuchungen stand die Entwicklung neuer präparativer Methoden zur Darstellung siliciumhaltiger Wirkstoffe und die Untersuchung ihrer pharmakologischen Wirksamkeit sowie die Synthese racemischer und enantiomerenreiner siliciumhaltiger alpha-Aminosäuren des beta-(Trimethylsilyl)alanin-Typs.","abstract_has_math":false,"creators":["Handmann, Vera Iris"],"institution":"Universität Würzburg","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Tacke, Reinhold"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002-04-09","date_published":"2002-04-09","updated_at":"2026-07-24T06:11:09Z","subjects":["Aminosäuren","Antipsychotika","Bioanorganik","Kristallstrukturanalyse","Muscarin Antagonisten","pharmakologisches Profil","Silicium","Synthese","amino acids","antipsychotics","bioinorganic chemistry","C/Si bioisosterism","crystal structure analysis","muscarinic antagonists"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/395","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tacke, Reinhold"]},{"key":"dc:creator","label":"Author","values":["Handmann, Vera Iris"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universität Würzburg"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Universität Würzburg"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aminosäuren","Antipsychotika","Bioanorganik","Kristallstrukturanalyse","Muscarin Antagonisten","pharmakologisches Profil","Silicium","Synthese","amino acids","antipsychotics","bioinorganic chemistry","C/Si bioisosterism","crystal structure analysis","muscarinic antagonists"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Im Rahmen der vorliegenden Arbeit wurden Beiträge zur C/Si-Bioisosterie und zur asymmetrischen Synthese neuer siliciumhaltiger alpha-Aminosäuren geleistet. Im Vordergrund der Untersuchungen stand die Entwicklung neuer präparativer Methoden zur Darstellung siliciumhaltiger Wirkstoffe und die Untersuchung ihrer pharmakologischen Wirksamkeit sowie die Synthese racemischer und enantiomerenreiner siliciumhaltiger alpha-Aminosäuren des beta-(Trimethylsilyl)alanin-Typs.","This work describes contributions to the field of C/Si bioisosterism and to the asymmetric synthesis of novel silicon-containing alpha-amino acids. The aim of these investigations was the development of new preparative methods for the synthesis of silicon-containing drugs and their pharmacological evaluation as well as the synthesis of racemic and enantiomerically pure silicon-containing alpha-amino acids of the beta-(trimethylsilyl)alanine type."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Studien zur C/Si-Bioisosterie","Studies on C/Si Bioisosterism"]}]}],"canonical_facts":{"dc:contributor":["Tacke, Reinhold"],"dc:creator":["Handmann, Vera Iris"],"dc:description.abstract":["Im Rahmen der vorliegenden Arbeit wurden Beiträge zur C/Si-Bioisosterie und zur asymmetrischen Synthese neuer siliciumhaltiger alpha-Aminosäuren geleistet. Im Vordergrund der Untersuchungen stand die Entwicklung neuer präparativer Methoden zur Darstellung siliciumhaltiger Wirkstoffe und die Untersuchung ihrer pharmakologischen Wirksamkeit sowie die Synthese racemischer und enantiomerenreiner siliciumhaltiger alpha-Aminosäuren des beta-(Trimethylsilyl)alanin-Typs.","This work describes contributions to the field of C/Si bioisosterism and to the asymmetric synthesis of novel silicon-containing alpha-amino acids. The aim of these investigations was the development of new preparative methods for the synthesis of silicon-containing drugs and their pharmacological evaluation as well as the synthesis of racemic and enantiomerically pure silicon-containing alpha-amino acids of the beta-(trimethylsilyl)alanine type."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universität Würzburg"],"dc:subject":["Aminosäuren","Antipsychotika","Bioanorganik","Kristallstrukturanalyse","Muscarin Antagonisten","pharmakologisches Profil","Silicium","Synthese","amino acids","antipsychotics","bioinorganic chemistry","C/Si bioisosterism","crystal structure analysis","muscarinic antagonists"],"dc:title":["Studien zur C/Si-Bioisosterie","Studies on C/Si Bioisosterism"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Universität Würzburg"]},"updated_at":"2026-07-24T06:11:09Z"}