{"id":{"repo_id":"wurz-thes","oai_identifier":"oai:opus.bibliothek.uni-wuerzburg.de:1200"},"canonical_url":"https://search.dev.ndltd.org/etd/wurz-thes/oai:opus.bibliothek.uni-wuerzburg.de:1200","repository":{"repo_id":"wurz-thes","name":"Universität Wüzburg","base_url":"https://opus.bibliothek.uni-wuerzburg.de/oai"},"display":{"title":"Cholesterinmetabolismus in Toxoplasma gondii : Klonierung und Nachweis der Funktion eines Acyl-CoA: Cholesterin Acyltransferase aehnlichen Enzyms - ein neuer Angriffspunkt fuer pharmakologische Intervention","abstract":"Ich praesentiere hier die Klonierung und Funktion eines ACAT-aehnlichen Enzyms von Toxoplasma gondii (T. gondii), das lebensnotwendig fuer T. gondii zu sein scheint. Medikamente, die gegen die menschliche ACAT gerichtet sind, erhoehen in geringen Konzentrationen die ACAT-Aktivitaet von T. gondii. In hoeheren Konzentrationen schraenken sie jedoch die Vitalitaet von T. gondii ein.","abstract_html":"Ich praesentiere hier die Klonierung und Funktion eines ACAT-aehnlichen Enzyms von Toxoplasma gondii (T. gondii), das lebensnotwendig fuer T. gondii zu sein scheint. Medikamente, die gegen die menschliche ACAT gerichtet sind, erhoehen in geringen Konzentrationen die ACAT-Aktivitaet von T. gondii. In hoeheren Konzentrationen schraenken sie jedoch die Vitalitaet von T. gondii ein.","abstract_has_math":false,"creators":["Quittnat, Friederike Susanne"],"institution":"Universität Würzburg","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Frosch, Matthias"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2005,"date_issued":"2005-06-21","date_published":"2005-06-21","updated_at":"2026-07-24T06:11:37Z","subjects":["Toxoplasma gondii","Cholesterin","Neutrallipide","ACAT","cholesterol","neutrallipids"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/1200","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Frosch, Matthias"]},{"key":"dc:creator","label":"Author","values":["Quittnat, Friederike Susanne"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universität Würzburg"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Universität Würzburg"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Toxoplasma gondii","Cholesterin","Neutrallipide","ACAT","cholesterol","neutrallipids"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Ich praesentiere hier die Klonierung und Funktion eines ACAT-aehnlichen Enzyms von Toxoplasma gondii (T. gondii), das lebensnotwendig fuer T. gondii zu sein scheint. Medikamente, die gegen die menschliche ACAT gerichtet sind, erhoehen in geringen Konzentrationen die ACAT-Aktivitaet von T. gondii. In hoeheren Konzentrationen schraenken sie jedoch die Vitalitaet von T. gondii ein.","Here I present the cloning and functional analysis of a Toxoplasma gondii (T. gondii) ACAT-like enzyme required for its viability. Drugs directed against the human ACAT when used at a low concentration increase the activity of the T. gondii ACAT. However when used at higher concentrations the vitality of T. gondii is reduced."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Cholesterinmetabolismus in Toxoplasma gondii : Klonierung und Nachweis der Funktion eines Acyl-CoA: Cholesterin Acyltransferase aehnlichen Enzyms - ein neuer Angriffspunkt fuer pharmakologische Intervention","Cholesterolmetabolism in Toxoplasma gondii: cloning and function of an ACAT-like enzyme - a new target for pharmacological intervention"]}]}],"canonical_facts":{"dc:contributor":["Frosch, Matthias"],"dc:creator":["Quittnat, Friederike Susanne"],"dc:description.abstract":["Ich praesentiere hier die Klonierung und Funktion eines ACAT-aehnlichen Enzyms von Toxoplasma gondii (T. gondii), das lebensnotwendig fuer T. gondii zu sein scheint. Medikamente, die gegen die menschliche ACAT gerichtet sind, erhoehen in geringen Konzentrationen die ACAT-Aktivitaet von T. gondii. In hoeheren Konzentrationen schraenken sie jedoch die Vitalitaet von T. gondii ein.","Here I present the cloning and functional analysis of a Toxoplasma gondii (T. gondii) ACAT-like enzyme required for its viability. Drugs directed against the human ACAT when used at a low concentration increase the activity of the T. gondii ACAT. However when used at higher concentrations the vitality of T. gondii is reduced."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universität Würzburg"],"dc:subject":["Toxoplasma gondii","Cholesterin","Neutrallipide","ACAT","cholesterol","neutrallipids"],"dc:title":["Cholesterinmetabolismus in Toxoplasma gondii : Klonierung und Nachweis der Funktion eines Acyl-CoA: Cholesterin Acyltransferase aehnlichen Enzyms - ein neuer Angriffspunkt fuer pharmakologische Intervention","Cholesterolmetabolism in Toxoplasma gondii: cloning and function of an ACAT-like enzyme - a new target for pharmacological intervention"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Universität Würzburg"]},"updated_at":"2026-07-24T06:11:37Z"}