Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.
Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes containing Heinz bodies in peripheral blood. The menstrual cycle apparently has no statistical affect on the increased ratio of Heinz body-containing erythrocytes to normal erythrocytes.
","abstract_html":"<p>Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.</p> <p>Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes containing Heinz bodies in peripheral blood. The menstrual cycle apparently has no statistical affect on the increased ratio of Heinz body-containing erythrocytes to normal erythrocytes.</p>","abstract_has_math":false,"creators":["Hu, Yenya"],"institution":null,"degree_name":"Master of Science","degree_level":null,"degree_discipline":"Department of Biology","degree_department":null,"school":null,"contributors":["M.R. Houston, F.R. Toman, C.A. Rinehart"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1992,"date_issued":"1992-05-01T07:00:00Z","date_published":"1992-05-01T07:00:00Z","updated_at":"2026-07-24T06:08:39Z","subjects":["Western Kentucky University","Biology","Hematology","Life Sciences","Medicine and Health Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.wku.edu/theses/1423","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["M.R. Houston, F.R. Toman, C.A. Rinehart"]},{"key":"dc:creator","label":"Author","values":["Hu, Yenya"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Department of Biology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Western Kentucky University","Biology","Hematology","Life Sciences","Medicine and Health Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.wku.edu/theses/1423"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.
Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes containing Heinz bodies in peripheral blood. The menstrual cycle apparently has no statistical affect on the increased ratio of Heinz body-containing erythrocytes to normal erythrocytes.
"]},{"key":"dc:title","label":"Title","values":["The Ratio of Heinz Body Formation in Different Hemoglobin Zurich Subjects"]}]}],"canonical_facts":{"dc:contributor":["M.R. Houston, F.R. Toman, C.A. Rinehart"],"dc:creator":["Hu, Yenya"],"dc:description.abstract":["Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.
Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes containing Heinz bodies in peripheral blood. The menstrual cycle apparently has no statistical affect on the increased ratio of Heinz body-containing erythrocytes to normal erythrocytes.
"],"dc:identifier":["https://digitalcommons.wku.edu/theses/1423"],"dc:subject":["Western Kentucky University","Biology","Hematology","Life Sciences","Medicine and Health Sciences"],"dc:title":["The Ratio of Heinz Body Formation in Different Hemoglobin Zurich Subjects"],"dc:type":["Thesis"],"thesis:degree_discipline":["Department of Biology"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T06:08:39Z"}