Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system.
Assigned levels of BHT were incorporated into the diet of New Zealand White rabbits with HSV-1 McKrae strain on the corneal surface of the eyes. The degree of infection was measured by a subjective assay. Rabbits receiving BHT in their diet consistently experienced lower levels of infection. The interpretation of this data is that orally administered BHT can be an effective inhibitor of primary infections by HSV in rabbits.
","abstract_html":"<p>Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system. </p> <p>Assigned levels of BHT were incorporated into the diet of New Zealand White rabbits with HSV-1 McKrae strain on the corneal surface of the eyes. The degree of infection was measured by a subjective assay. Rabbits receiving BHT in their diet consistently experienced lower levels of infection. The interpretation of this data is that orally administered BHT can be an effective inhibitor of primary infections by HSV in rabbits.</p>","abstract_has_math":false,"creators":["Carson, Donald"],"institution":null,"degree_name":"Master of Science","degree_level":null,"degree_discipline":"Department of Biology","degree_department":null,"school":null,"contributors":["Thomas Coohill"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1983,"date_issued":"1983-11-01T08:00:00Z","date_published":"1983-11-01T08:00:00Z","updated_at":"2026-07-24T06:08:39Z","subjects":["Western Kentucky University","Viruses","Animal Testing","Biology","Diseases","Laboratory and Basic Science Research","Virus Diseases"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.wku.edu/theses/1376","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Thomas Coohill"]},{"key":"dc:creator","label":"Author","values":["Carson, Donald"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Department of Biology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Western Kentucky University","Viruses","Animal Testing","Biology","Diseases","Laboratory and Basic Science Research","Virus Diseases"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.wku.edu/theses/1376"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system.
Assigned levels of BHT were incorporated into the diet of New Zealand White rabbits with HSV-1 McKrae strain on the corneal surface of the eyes. The degree of infection was measured by a subjective assay. Rabbits receiving BHT in their diet consistently experienced lower levels of infection. The interpretation of this data is that orally administered BHT can be an effective inhibitor of primary infections by HSV in rabbits.
"]},{"key":"dc:title","label":"Title","values":["The Effect of Orally Administered Butylated Hydroxytoluene on Herpes Simplex Keratitis"]}]}],"canonical_facts":{"dc:contributor":["Thomas Coohill"],"dc:creator":["Carson, Donald"],"dc:description.abstract":["Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system.
Assigned levels of BHT were incorporated into the diet of New Zealand White rabbits with HSV-1 McKrae strain on the corneal surface of the eyes. The degree of infection was measured by a subjective assay. Rabbits receiving BHT in their diet consistently experienced lower levels of infection. The interpretation of this data is that orally administered BHT can be an effective inhibitor of primary infections by HSV in rabbits.
"],"dc:identifier":["https://digitalcommons.wku.edu/theses/1376"],"dc:subject":["Western Kentucky University","Viruses","Animal Testing","Biology","Diseases","Laboratory and Basic Science Research","Virus Diseases"],"dc:title":["The Effect of Orally Administered Butylated Hydroxytoluene on Herpes Simplex Keratitis"],"dc:type":["Thesis"],"thesis:degree_discipline":["Department of Biology"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T06:08:39Z"}