Western Kentucky University
Size Dependent Antimicrobial Properties of Sugar Encapsulated Gold Nanoparticles
Abstract
dc:description.abstract<p>The antimicrobial properties of dextrose encapsulated gold nanoparticles (dGNPs) with average diameters of 25 nm, 60 nm, and 120 nm (± 5 nm) synthesized by green chemistry principles were investigated against both Gram-negative and Gram-positive bacteria. Studies were performed involving the effect of the dGNPs on the growth, morphology and the ultrastructural properties of bacteria. dGNPs were found to have significant dose dependent antibacterial activity which was directly proportional to their size and also their concentration. The microbial assays revealed the dGNPs to be bacteriostatic as well as bactericidal. The dGNPs exhibited their bactericidal action through the disruption of the bacterial cell membrane causing leakage of cytoplasmic content. The overall outcomes of this study suggest that dGNPs hold promise as a potent antimicrobial agent against a wide range of disease causing bacteria and can control and prevent possible infections or diseases.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science
- Discipline thesis:degree_discipline
- Department of Chemistry
- Year
- 2012
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Vangala, Lakshmisri Manisha
- Contributors dc:contributor
-
- Dr.Rajalingam Dakshinamurthy, Director, Dr.Cathleen Webb, Dr.Stuart Burris
Subjects
dc:subject × 6Identifiers
dc:identifier.*- Repository record dc:identifier
- https://digitalcommons.wku.edu/theses/1166
- OAI identifier oai:identifier
- oai:digitalcommons.wku.edu:theses-2169