{"id":{"repo_id":"wku-diss","oai_identifier":"oai:digitalcommons.wku.edu:theses-1787"},"canonical_url":"https://search.dev.ndltd.org/etd/wku-diss/oai:digitalcommons.wku.edu:theses-1787","repository":{"repo_id":"wku-diss","name":"Western Kentucky University","base_url":"https://digitalcommons.wku.edu/do/oai/"},"display":{"title":"The Beneficial Effect of Vitamin E and Selenium During Experimental Chagas' Disease","abstract":"The present study was conducted to determine if vitamin E and selenium could have a positive synergistic effect during experimental Chagas' disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In the second phase, 20 female C3HeB/FeJ mice were infected while receiving 400 IU/kg vitamin E plus selenium supplementation of 2 ppm, 4 ppm, 8 ppm, 16 ppm in their drinking water. The results demonstrate that vitamin E does have a protective effect during experimental Chagas' disease. There was a statistically significant difference (p<0.05) observed between the vitamin E-deficient mice and mice supplemented with vitamin E. The results of this study also suggest that combined vitamin E and selenium supplementation provides an even greater benefit than either antioxidant alone in mice infected with T. cruzi. A statistically significant difference was observed (p<0.01) between vitamin E supplemented mice and mice supplemented with vitamin E and selenium. The beneficial effects observed included: reduced parasitemia, increased survival rate, and reduced weight loss during infection. In this study, the combination of 400 IU/kg vitamin E and 8 ppm selenium provided the best overall protective effect during experimental Chagas' disease.","abstract_html":"The present study was conducted to determine if vitamin E and selenium could have a positive synergistic effect during experimental Chagas&#x27; disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In the second phase, 20 female C3HeB/FeJ mice were infected while receiving 400 IU/kg vitamin E plus selenium supplementation of 2 ppm, 4 ppm, 8 ppm, 16 ppm in their drinking water. The results demonstrate that vitamin E does have a protective effect during experimental Chagas&#x27; disease. There was a statistically significant difference (p&lt;0.05) observed between the vitamin E-deficient mice and mice supplemented with vitamin E. The results of this study also suggest that combined vitamin E and selenium supplementation provides an even greater benefit than either antioxidant alone in mice infected with T. cruzi. A statistically significant difference was observed (p&lt;0.01) between vitamin E supplemented mice and mice supplemented with vitamin E and selenium. The beneficial effects observed included: reduced parasitemia, increased survival rate, and reduced weight loss during infection. In this study, the combination of 400 IU/kg vitamin E and 8 ppm selenium provided the best overall protective effect during experimental Chagas&#x27; disease.","abstract_has_math":false,"creators":["Hou, Yue"],"institution":null,"degree_name":"Master of Science","degree_level":null,"degree_discipline":"Department of Biology","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1997,"date_issued":"1997-08-01T07:00:00Z","date_published":"1997-08-01T07:00:00Z","updated_at":"2026-07-24T06:07:48Z","subjects":["Medical Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.wku.edu/theses/784","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Hou, Yue"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Department of Biology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Medical Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.wku.edu/theses/784"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The present study was conducted to determine if vitamin E and selenium could have a positive synergistic effect during experimental Chagas' disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In the second phase, 20 female C3HeB/FeJ mice were infected while receiving 400 IU/kg vitamin E plus selenium supplementation of 2 ppm, 4 ppm, 8 ppm, 16 ppm in their drinking water. The results demonstrate that vitamin E does have a protective effect during experimental Chagas' disease. There was a statistically significant difference (p<0.05) observed between the vitamin E-deficient mice and mice supplemented with vitamin E. The results of this study also suggest that combined vitamin E and selenium supplementation provides an even greater benefit than either antioxidant alone in mice infected with T. cruzi. A statistically significant difference was observed (p<0.01) between vitamin E supplemented mice and mice supplemented with vitamin E and selenium. The beneficial effects observed included: reduced parasitemia, increased survival rate, and reduced weight loss during infection. In this study, the combination of 400 IU/kg vitamin E and 8 ppm selenium provided the best overall protective effect during experimental Chagas' disease."]},{"key":"dc:title","label":"Title","values":["The Beneficial Effect of Vitamin E and Selenium During Experimental Chagas' Disease"]}]}],"canonical_facts":{"dc:creator":["Hou, Yue"],"dc:description.abstract":["The present study was conducted to determine if vitamin E and selenium could have a positive synergistic effect during experimental Chagas' disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In the second phase, 20 female C3HeB/FeJ mice were infected while receiving 400 IU/kg vitamin E plus selenium supplementation of 2 ppm, 4 ppm, 8 ppm, 16 ppm in their drinking water. The results demonstrate that vitamin E does have a protective effect during experimental Chagas' disease. There was a statistically significant difference (p<0.05) observed between the vitamin E-deficient mice and mice supplemented with vitamin E. The results of this study also suggest that combined vitamin E and selenium supplementation provides an even greater benefit than either antioxidant alone in mice infected with T. cruzi. A statistically significant difference was observed (p<0.01) between vitamin E supplemented mice and mice supplemented with vitamin E and selenium. The beneficial effects observed included: reduced parasitemia, increased survival rate, and reduced weight loss during infection. In this study, the combination of 400 IU/kg vitamin E and 8 ppm selenium provided the best overall protective effect during experimental Chagas' disease."],"dc:identifier":["https://digitalcommons.wku.edu/theses/784"],"dc:subject":["Medical Sciences"],"dc:title":["The Beneficial Effect of Vitamin E and Selenium During Experimental Chagas' Disease"],"dc:type":["Thesis"],"thesis:degree_discipline":["Department of Biology"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T06:07:48Z"}