The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives

Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine are dominant; at lower Pt: methionine ratios, a bis-methionine product is formed. The en ligand is displaced by methionine but not N-acetylmethionine.

Name thesis:degree_name

Master of Science

Discipline thesis:degree_discipline

Department of Chemistry

Year

2010

Author dc:creator

• Liao, Yueh Ying

Contributors dc:contributor

• Dr. Kevin Williams (Director), Dr. Cathleen J. Webb, Dr. Lester Pesterfield

• cisplatin
• platinum anti-cancer drugs
• chemotherapy research
• Cancer Biology
• Inorganic Chemistry
• Medicinal-Pharmaceutical Chemistry

Repository record dc:identifier

https://digitalcommons.wku.edu/theses/153

OAI identifier oai:identifier

oai:digitalcommons.wku.edu:theses-1154