{"id":{"repo_id":"wichita-thes","oai_identifier":"oai:soar.wichita.edu:10057/2382"},"canonical_url":"https://search.dev.ndltd.org/etd/wichita-thes/oai:soar.wichita.edu:10057/2382","repository":{"repo_id":"wichita-thes","name":"Wichita State University","base_url":"https://soar.wichita.edu/oai/request"},"display":{"title":"Studies towards small-molecule-receptors selective for phospholipid anionic head groups in bacterial membranes","abstract":"Receptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the phosphate containing head group of bacterial membrane fatty acids was conceptualized as part of a possible broad spectrum antibiotic. The receptor and several related derivatives were synthesized over fourteen steps. The most important step which involved placing ureidomethylene groups to a bis‐phenolic scaffold was developed as a novel method. The method was probed for scope and utility with a variety of aromatic nucleophiles. The aforementioned anion receptors were tested for binding capabilities against several inorganic anions, and against a synthetic tetrabutylammonium salt of a phospholipid. Several of the derivatives were also tested for antibiotic activity against several species of gram negative bacteria. Finally, the receptors were used to bind chloride anion in solvents containing a variable amount of water to determine if the presence of water would result in stronger anion binding.","abstract_html":"Receptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the phosphate containing head group of bacterial membrane fatty acids was conceptualized as part of a possible broad spectrum antibiotic. The receptor and several related derivatives were synthesized over fourteen steps. The most important step which involved placing ureidomethylene groups to a bis‐phenolic scaffold was developed as a novel method. The method was probed for scope and utility with a variety of aromatic nucleophiles. The aforementioned anion receptors were tested for binding capabilities against several inorganic anions, and against a synthetic tetrabutylammonium salt of a phospholipid. Several of the derivatives were also tested for antibiotic activity against several species of gram negative bacteria. Finally, the receptors were used to bind chloride anion in solvents containing a variable amount of water to determine if the presence of water would result in stronger anion binding.","abstract_has_math":false,"creators":["Meece, Frederick A."],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-05","date_published":"2009-05","updated_at":"2026-07-24T06:06:11Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10057/2382"],"render_values":[{"text":"hdl:10057/2382","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2009-05"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10057/2382"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["Receptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the phosphate containing head group of bacterial membrane fatty acids was conceptualized as part of a possible broad spectrum antibiotic. The receptor and several related derivatives were synthesized over fourteen steps. The most important step which involved placing ureidomethylene groups to a bis‐phenolic scaffold was developed as a novel method. The method was probed for scope and utility with a variety of aromatic nucleophiles. The aforementioned anion receptors were tested for binding capabilities against several inorganic anions, and against a synthetic tetrabutylammonium salt of a phospholipid. Several of the derivatives were also tested for antibiotic activity against several species of gram negative bacteria. Finally, the receptors were used to bind chloride anion in solvents containing a variable amount of water to determine if the presence of water would result in stronger anion binding."]},{"key":"dc:title","label":"Title","values":["Studies towards small-molecule-receptors selective for phospholipid anionic head groups in bacterial membranes"]}]}],"canonical_facts":{"dc:date.issued":["2009-05"],"dc:description.other":["Receptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the phosphate containing head group of bacterial membrane fatty acids was conceptualized as part of a possible broad spectrum antibiotic. The receptor and several related derivatives were synthesized over fourteen steps. The most important step which involved placing ureidomethylene groups to a bis‐phenolic scaffold was developed as a novel method. The method was probed for scope and utility with a variety of aromatic nucleophiles. The aforementioned anion receptors were tested for binding capabilities against several inorganic anions, and against a synthetic tetrabutylammonium salt of a phospholipid. Several of the derivatives were also tested for antibiotic activity against several species of gram negative bacteria. Finally, the receptors were used to bind chloride anion in solvents containing a variable amount of water to determine if the presence of water would result in stronger anion binding."],"dc:identifier":["hdl:10057/2382"],"dc:title":["Studies towards small-molecule-receptors selective for phospholipid anionic head groups in bacterial membranes"],"dc:type":["Dissertation"]},"updated_at":"2026-07-24T06:06:11Z"}