{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/93055"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/93055","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE","abstract":"Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.","abstract_html":"Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.","abstract_has_math":false,"creators":["Michalson, Kristofer"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-27T22:02:23Z","subjects":["Diastolic Dysfunction"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/93055","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Michalson, Kristofer"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-01-11T09:35:18Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-01-10T09:30:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Diastolic Dysfunction"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/93055"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear."]},{"key":"dc:title","label":"Title","values":["FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE"]}]}],"canonical_facts":{"dc:creator":["Michalson, Kristofer"],"dc:date.accessioned":["2019-01-11T09:35:18Z"],"dc:date.available":["2021-01-10T09:30:10Z"],"dc:date.issued":["2018"],"dc:description.abstract":["Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear."],"dc:identifier.uri":["http://hdl.handle.net/10339/93055"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Diastolic Dysfunction"],"dc:title":["FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:23Z"}