AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS

The purpose of this study was to investigate the regulation of SAMHD1 and its relation to nucleotide metabolism and cell cycle progression. Phosphorylation of SAMHD1 is the most extensively documented means of regulation. While questions still remain regarding regulation of SAMHD1 by phosphorylation, this work investigates an alternative mechanism of regulation. A major signaling pathway that has not been investigated with regards to SAMHD1 regulation is redox biology. Redox biology is emerging as a central regulator in myriad cellular processes including cell cycle progression, cellular metabolism, and cell signaling. Given the role that nucleotide metabolism plays in these processes, this study was undertaken to test the hypothesis that SAMHD1 is a redox regulated enzyme and that redox signaling is important for modulating SAMHD1 activity in vivo.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2017

Author dc:creator

• Mauney, Christopher Holbrook

• Aicardi-Goutieres

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/82241

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/82241