{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/82227"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/82227","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Development and Validation of a Brain Phantom for Therapeutic Cooling Devices","abstract":"Tissue cooling has been proven as a viable therapy for multiple conditions and injuries, and has been applied to the brain to treat epilepsy and concussions, leading to improved long-term outcomes. To facilitate the study of temperature reduction as a function of various cooling methods, a thermal brain phantom was developed and analyzed. The phantom is composed of a granular hydrogel through which is circulated 37 degree water, representing blood perfusion. The phantom was tested in a series of cooling trials using a fluid-cooled cooling block during which the perfusion rate was varied. Results were compared against a validated finite difference (FD) model. The model was used to calculate steady state cooling at a depth of 5 mm for all flow rates, for both the phantom experiment and a model of the brain. The FD phantom model showed good agreement with the empirical phantom results. Furthermore, the empirical phantom agreed with the predicted brain response within 3.5% at physiological flow, suggesting a biofidelic thermal response. The phantom will be used as a platform for future studies of thermally-mediated therapies applied to the cerebral cortex.","abstract_html":"Tissue cooling has been proven as a viable therapy for multiple conditions and injuries, and has been applied to the brain to treat epilepsy and concussions, leading to improved long-term outcomes. To facilitate the study of temperature reduction as a function of various cooling methods, a thermal brain phantom was developed and analyzed. The phantom is composed of a granular hydrogel through which is circulated 37 degree water, representing blood perfusion. The phantom was tested in a series of cooling trials using a fluid-cooled cooling block during which the perfusion rate was varied. Results were compared against a validated finite difference (FD) model. The model was used to calculate steady state cooling at a depth of 5 mm for all flow rates, for both the phantom experiment and a model of the brain. The FD phantom model showed good agreement with the empirical phantom results. Furthermore, the empirical phantom agreed with the predicted brain response within 3.5% at physiological flow, suggesting a biofidelic thermal response. The phantom will be used as a platform for future studies of thermally-mediated therapies applied to the cerebral cortex.","abstract_has_math":false,"creators":["Packett, Ryan"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017","date_published":"2017","updated_at":"2026-07-27T22:02:11Z","subjects":["brain"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/82227","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Packett, Ryan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-06-15T08:36:07Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-05-15T08:30:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2017"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["brain"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/82227"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Tissue cooling has been proven as a viable therapy for multiple conditions and injuries, and has been applied to the brain to treat epilepsy and concussions, leading to improved long-term outcomes. To facilitate the study of temperature reduction as a function of various cooling methods, a thermal brain phantom was developed and analyzed. The phantom is composed of a granular hydrogel through which is circulated 37 degree water, representing blood perfusion. The phantom was tested in a series of cooling trials using a fluid-cooled cooling block during which the perfusion rate was varied. Results were compared against a validated finite difference (FD) model. The model was used to calculate steady state cooling at a depth of 5 mm for all flow rates, for both the phantom experiment and a model of the brain. The FD phantom model showed good agreement with the empirical phantom results. Furthermore, the empirical phantom agreed with the predicted brain response within 3.5% at physiological flow, suggesting a biofidelic thermal response. The phantom will be used as a platform for future studies of thermally-mediated therapies applied to the cerebral cortex."]},{"key":"dc:title","label":"Title","values":["Development and Validation of a Brain Phantom for Therapeutic Cooling Devices"]}]}],"canonical_facts":{"dc:creator":["Packett, Ryan"],"dc:date.accessioned":["2017-06-15T08:36:07Z"],"dc:date.available":["2022-05-15T08:30:10Z"],"dc:date.issued":["2017"],"dc:description.abstract":["Tissue cooling has been proven as a viable therapy for multiple conditions and injuries, and has been applied to the brain to treat epilepsy and concussions, leading to improved long-term outcomes. To facilitate the study of temperature reduction as a function of various cooling methods, a thermal brain phantom was developed and analyzed. The phantom is composed of a granular hydrogel through which is circulated 37 degree water, representing blood perfusion. The phantom was tested in a series of cooling trials using a fluid-cooled cooling block during which the perfusion rate was varied. Results were compared against a validated finite difference (FD) model. The model was used to calculate steady state cooling at a depth of 5 mm for all flow rates, for both the phantom experiment and a model of the brain. The FD phantom model showed good agreement with the empirical phantom results. Furthermore, the empirical phantom agreed with the predicted brain response within 3.5% at physiological flow, suggesting a biofidelic thermal response. The phantom will be used as a platform for future studies of thermally-mediated therapies applied to the cerebral cortex."],"dc:identifier.uri":["http://hdl.handle.net/10339/82227"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["brain"],"dc:title":["Development and Validation of a Brain Phantom for Therapeutic Cooling Devices"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:02:11Z"}