Hormone Responses to Two Different Energy Restriction Programs

There is a general decrease in satiety hormones (glucagon-like peptide 1 (GLP-1) and leptin) and an increase in hunger hormones (ghrelin) with weight loss, however results are conflicting. Currently, no studies have examined hormone levels comparing different approaches in calorie reductions for weight loss. PURPOSE: The primary purpose was to compare plasma levels of ghrelin, GLP-1, and leptin in obese participants undergoing a traditional low calorie diet (LCD) vs. those on a calorie tapered program (TAPER). METHODOLOGY: Eight obese participants were randomized into the LCD (immediate caloric reduction) or a taper diet (gradual caloric reduction) for 6 weeks. Fasting and postprandial hormone levels after a meal challenge were taken at week 0 and week 6. STATISTICAL ANALYSIS: T tests were performed to examine differences between groups in change of hormone levels from week 0 to week 6. Effect sizes were calculated. RESULTS: Weight loss was 6.1% in LCD and 5.3% for TAPER. The intervention had a moderate effect on fasting ghrelin, change in postprandial ghrelin and GLP-1 and a large effect on fasting GLP-1. CONCLUSION: These findings suggest that a gradual caloric reduction could lower ghrelin and increase GLP-1 after a meal more so than an immediate caloric reduction.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2017

Author dc:creator

• Dibert, Lauren

• energy restriction

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/82203

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/82203