ALTERED HEMODYNAMIC, NEUROHUMORAL, AND BRAIN METABOLITE PROFILES IN CHILDREN WITH ORTHOSTATIC INTOLERANCE AND CHRONIC NAUSEA

Orthostatic Intolerance (OI) is a type of autonomic dysfunction affecting >500,000 adults and children in the United States. Upon standing, subjects with OI have impaired blood pressure (BP) regulation that leads to debilitating symptoms of dizziness, fatigue, nausea, and fainting. The development of OI is poorly understood and a variety of cardiovascular responses occur with standing including exaggerated tachycardia, hypotension, and syncope. OI is associated with functional gastrointestinal (GI) symptoms, specifically chronic nausea, in children and exaggerated neurohumoral responses in adults. The heterogeneity in symptoms of autonomic dysfunction highlights the importance of defining phenotypic profiles to ensure effective management and treatment of the patient-specific cardiovascular (CV) and gastrointestinal (GI) symptoms. To do this, it is critical to identify key factors that regulate autonomic outflow in supine and upright positions in OI. To this end, our goals were to define phenotypes of OI and chronic nausea in children based upon measures of hemodynamic and neurohumoral responses to orthostatic challenge and to evaluate the relationship between supine cerebral metabolites to autonomic function.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Wagoner, Ashley L

• arginine vasopressin

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/59293

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/59293