{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/59274"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/59274","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Studies in Peroxiredoxin Hyperoxidation Sensitivity","abstract":"Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy.","abstract_html":"Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy.","abstract_has_math":false,"creators":["Bolduc, Jesalyn"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T22:01:58Z","subjects":["crystallography"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/59274","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Bolduc, Jesalyn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-05-21T08:35:36Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-20T08:30:11Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["crystallography"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/59274"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy."]},{"key":"dc:title","label":"Title","values":["Studies in Peroxiredoxin Hyperoxidation Sensitivity"]}]}],"canonical_facts":{"dc:creator":["Bolduc, Jesalyn"],"dc:date.accessioned":["2016-05-21T08:35:36Z"],"dc:date.available":["2018-05-20T08:30:11Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy."],"dc:identifier.uri":["http://hdl.handle.net/10339/59274"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["crystallography"],"dc:title":["Studies in Peroxiredoxin Hyperoxidation Sensitivity"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}