A study of the neuropharmacology and genetics of dopamine: using common, preclinical behavioral techniques, cognitive batteries, and genetic analyses to unravel the dopaminergic system

Dopamine is the most common neurotransmitter in the mammalian brain and is a key modulator of reward-related behaviors. Through the use of animal models, the dopaminergic system has been implicated in several neuropsychiatric disorders. Furthermore, the application of genetic technologies has helped uncover how modulation of dopaminergic signaling leads to modification of normal behavior and contributes to negative phenotypes and symptoms associated with diseases like attention-deficit/hyperactivity disorder, cocaine dependence, and obesity. This dissertation explores a number of behaviors, learned and unconditioned, and the contribution of dopaminergic neurotransmission to each by using both human and non-human primates as subjects.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Martelle, Susan Elizabeth

• Cognition

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/59260

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/59260