ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT

The behavioral and neurochemical effects of amphetamine have been studied since the beginnings of neuroscience; however, many questions still remain as to its precise mechanisms of action on neurotransmission, and the resulting effects on behavior. Given that amphetamine is one of the most widely prescribed stimulants, and is also abused off-label, it is critical to understand the mechanisms of amphetamine actions to drive the design of improved pharmacotherapeutics with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Siciliano, Cody A.

• addiction

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57442

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57442