{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/57275"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/57275","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort","abstract":"Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression.","abstract_html":"Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression.","abstract_has_math":false,"creators":["Cammarata, Michael Wesley"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-27T22:01:58Z","subjects":["DNA Methylation"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/57275","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Cammarata, Michael Wesley"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-08-25T08:35:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-02-24T09:30:09Z"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["DNA Methylation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/57275"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression."]},{"key":"dc:title","label":"Title","values":["DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort"]}]}],"canonical_facts":{"dc:creator":["Cammarata, Michael Wesley"],"dc:date.accessioned":["2015-08-25T08:35:39Z"],"dc:date.available":["2016-02-24T09:30:09Z"],"dc:date.issued":["2015"],"dc:description.abstract":["Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression."],"dc:identifier.uri":["http://hdl.handle.net/10339/57275"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["DNA Methylation"],"dc:title":["DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:01:58Z"}