{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/57274"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/57274","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates","abstract":"The genetically and phenotypically diverse bacterium nontypeable <i>Haemophilus influenzae</i> (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. Developing a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population.","abstract_html":"The genetically and phenotypically diverse bacterium nontypeable &lt;i&gt;Haemophilus influenzae&lt;/i&gt; (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. Developing a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population.","abstract_has_math":false,"creators":["Reimche, Jennifer"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-27T22:01:58Z","subjects":["Antibiotics"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/57274","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Reimche, Jennifer"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-08-25T08:35:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-08-24T08:30:12Z"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Antibiotics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/57274"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The genetically and phenotypically diverse bacterium nontypeable <i>Haemophilus influenzae</i> (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. Developing a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population."]},{"key":"dc:title","label":"Title","values":["Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates"]}]}],"canonical_facts":{"dc:creator":["Reimche, Jennifer"],"dc:date.accessioned":["2015-08-25T08:35:39Z"],"dc:date.available":["2017-08-24T08:30:12Z"],"dc:date.issued":["2015"],"dc:description.abstract":["The genetically and phenotypically diverse bacterium nontypeable <i>Haemophilus influenzae</i> (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. Developing a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire population."],"dc:identifier.uri":["http://hdl.handle.net/10339/57274"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Antibiotics"],"dc:title":["Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}