{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/57262"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/57262","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION","abstract":"The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-).","abstract_html":"The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-).","abstract_has_math":false,"creators":["Jennings, Ryan"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-27T22:01:58Z","subjects":["herpesviridae"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/57262","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Jennings, Ryan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-08-25T08:35:34Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-08-25T08:35:34Z"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["herpesviridae"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/57262"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-)."]},{"key":"dc:title","label":"Title","values":["THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION"]}]}],"canonical_facts":{"dc:creator":["Jennings, Ryan"],"dc:date.accessioned":["2015-08-25T08:35:34Z"],"dc:date.available":["2015-08-25T08:35:34Z"],"dc:date.issued":["2015"],"dc:description.abstract":["The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established roles for CD8+ T cells in controlling gammaherpesvirus infections, the mechanisms that govern the generation and enhancement of the gammaherpesvirus-specific CD8+ T response are unknown. This study was undertaken to evaluate the role of type I IFNs in MHV68-specific CD8+ T cell expansion, differentiation, and functionality utilizing a murine type I IFN receptor knockout strain (IFNAR1-/-)."],"dc:identifier.uri":["http://hdl.handle.net/10339/57262"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["herpesviridae"],"dc:title":["THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:58Z"}