MODELING HEART DISEASE OF PATIENTS WITH MUSCULAR DYSTROPHY USING INDUCED PLURIPOTENT STEM CELLS

Dystrophin deficient cardiomyopathy is a hereditary disorder resulting from dystrophin gene mutation. All patients inevitably develop cardiomyopathy and 30%-50% of them succumb to congestive heart failure. The mechanism of dystrophic cardiomyopathy is still elusive, partly due to the scarce human material to study this disease. Therefore, we propose to create dystrophin deficient cardiomyopathy in vitro using DMD patient cardiomyocytes derived from induced pluripotent stem cells (iPSC). By converting adult somatic cells to iPSCs and further differentiate into cardiac lineage, a vast number of cardiomyocytes can be manufactured to explore disease etiology and conduct drug screening.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Guan, Xuan

• adeno associated virus

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57259

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57259