SYNTHESIS OF SMALL MOLECULE PROBES FOR PROTEIN SULFENIC ACIDS

Hydrogen peroxide (H2O2) and its metabolites participate in cellular redox homeostasis and have become well documented in recent years as messengers in signal transduction. One important mechanism by which redox-based signaling happens is reversible oxidation of cysteine residues forming cysteine sulfenic acids (Cys-SOH) which are thought to be one of the most prevalent cysteine modifications, and formation of these species reversibly alters protein function. However, the subtle balance between oxidative signaling and damage is still unclear because of a lack of sensitive, stable, readily detectable traps for these intermediates.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Mukherjee, Rajeswari

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57191

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57191