Development of the African Green Monkey as a Model for Complement-Mediated Neutralization of Myxoviruses

Complement (C') plays a significant role in the innate immune response to myxoviruses such as parainfluenza viruses (PIV) and influenza A virus (IAV). The regulation of C' activity to balance control of virus spread while preventing a hyperinflammatory environment can have important implications for human health. The overall goal of our work was to develop the African green monkey (AGM) as a model to dissect the role of C' in neutralization of myxoviruses. First, we determined the contribution of C' to the neutralizing capacity of antibodies (Abs) elicited by respiratory tract infection of AGMs with PIV. Then we shifted to assessing changes in C' response to IAV infection during pregnancy--a physiologic environment that requires alterations in C' to maintain a healthy inflammatory environment for the mother and developing fetus.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Mayer, Anne E.

• Complement

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57172

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57172