{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/39396"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/39396","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Viral and Bacterial Polymicrobial Interactions with Streptococcus pneumoniae in Otitis Media","abstract":"The major pediatric disease otitis media is caused by a variety of bacterial and viral etiological agents, which frequently act in combination to induce polymicrobial middle ear disease. <italic>Streptococcus pneumoniae</italic> is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of <italic>S. pneumoniae</italic> with nontypeable <italic>Haemophilus influenzae</italic>, the other leading bacterial cause of otitis media, and with adenovirus, a major cause of upper respiratory infections.","abstract_html":"The major pediatric disease otitis media is caused by a variety of bacterial and viral etiological agents, which frequently act in combination to induce polymicrobial middle ear disease. &lt;italic&gt;Streptococcus pneumoniae&lt;/italic&gt; is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of &lt;italic&gt;S. pneumoniae&lt;/italic&gt; with nontypeable &lt;italic&gt;Haemophilus influenzae&lt;/italic&gt;, the other leading bacterial cause of otitis media, and with adenovirus, a major cause of upper respiratory infections.","abstract_has_math":false,"creators":["Murrah, Kyle Allen"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-27T22:01:46Z","subjects":["Adenovirus"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/39396","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Murrah, Kyle Allen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-09-10T08:35:22Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-09-10T08:30:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Adenovirus"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/39396"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The major pediatric disease otitis media is caused by a variety of bacterial and viral etiological agents, which frequently act in combination to induce polymicrobial middle ear disease. <italic>Streptococcus pneumoniae</italic> is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of <italic>S. pneumoniae</italic> with nontypeable <italic>Haemophilus influenzae</italic>, the other leading bacterial cause of otitis media, and with adenovirus, a major cause of upper respiratory infections."]},{"key":"dc:title","label":"Title","values":["Viral and Bacterial Polymicrobial Interactions with Streptococcus pneumoniae in Otitis Media"]}]}],"canonical_facts":{"dc:creator":["Murrah, Kyle Allen"],"dc:date.accessioned":["2014-09-10T08:35:22Z"],"dc:date.available":["2015-09-10T08:30:10Z"],"dc:date.issued":["2014"],"dc:description.abstract":["The major pediatric disease otitis media is caused by a variety of bacterial and viral etiological agents, which frequently act in combination to induce polymicrobial middle ear disease. <italic>Streptococcus pneumoniae</italic> is one of the two most commonly isolated bacterial pathogens of otitis media. This dissertation examines interactions of <italic>S. pneumoniae</italic> with nontypeable <italic>Haemophilus influenzae</italic>, the other leading bacterial cause of otitis media, and with adenovirus, a major cause of upper respiratory infections."],"dc:identifier.uri":["http://hdl.handle.net/10339/39396"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Adenovirus"],"dc:title":["Viral and Bacterial Polymicrobial Interactions with Streptococcus pneumoniae in Otitis Media"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:46Z"}