{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/39307"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/39307","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer","abstract":"Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options.","abstract_html":"Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options.","abstract_has_math":false,"creators":["Arter, Alison"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-27T22:01:46Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/39307","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Arter, Alison"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-10T08:35:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-07-10T08:30:09Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/39307"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options."]},{"key":"dc:title","label":"Title","values":["Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer"]}]}],"canonical_facts":{"dc:creator":["Arter, Alison"],"dc:date.accessioned":["2014-07-10T08:35:38Z"],"dc:date.available":["2015-07-10T08:30:09Z"],"dc:date.issued":["2014"],"dc:description.abstract":["Approximately 40,000 women in the U.S. die from breast cancer annually. An estimated 15% of all breast cancers are triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is highly-aggressive with greater patient mortality rates compared with other breast cancer subtypes, necessitating development of novel treatment options."],"dc:identifier.uri":["http://hdl.handle.net/10339/39307"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:title":["Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:46Z"}