{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/39021"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/39021","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR","abstract":"Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation studies have accelerated axon outgrowth up to three times the normal rate for up to 48 hours and have shown electric fields up to 600 um were able to direct and accelerate axon outgrowth across the gap. These data led to the hypothesis that repeated electric field gradients up to 600 um would maximize axonal outgrowth. The purpose of this project was to develop and evaluate biphasic conducting materials capable of producing repeated electric field gradients.","abstract_html":"Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation studies have accelerated axon outgrowth up to three times the normal rate for up to 48 hours and have shown electric fields up to 600 um were able to direct and accelerate axon outgrowth across the gap. These data led to the hypothesis that repeated electric field gradients up to 600 um would maximize axonal outgrowth. The purpose of this project was to develop and evaluate biphasic conducting materials capable of producing repeated electric field gradients.","abstract_has_math":false,"creators":["Rosenbalm, Tabitha Nichole"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-27T22:01:39Z","subjects":["bioresorbable conduit"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/39021","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Rosenbalm, Tabitha Nichole"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-08-23T08:35:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["bioresorbable conduit"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/39021"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation studies have accelerated axon outgrowth up to three times the normal rate for up to 48 hours and have shown electric fields up to 600 um were able to direct and accelerate axon outgrowth across the gap. These data led to the hypothesis that repeated electric field gradients up to 600 um would maximize axonal outgrowth. The purpose of this project was to develop and evaluate biphasic conducting materials capable of producing repeated electric field gradients."]},{"key":"dc:title","label":"Title","values":["REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR"]}]}],"canonical_facts":{"dc:creator":["Rosenbalm, Tabitha Nichole"],"dc:date.accessioned":["2013-08-23T08:35:16Z"],"dc:date.issued":["2013"],"dc:description.abstract":["Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers have focused on methods to accelerate axon outgrowth. Electrical stimulation studies have accelerated axon outgrowth up to three times the normal rate for up to 48 hours and have shown electric fields up to 600 um were able to direct and accelerate axon outgrowth across the gap. These data led to the hypothesis that repeated electric field gradients up to 600 um would maximize axonal outgrowth. The purpose of this project was to develop and evaluate biphasic conducting materials capable of producing repeated electric field gradients."],"dc:identifier.uri":["http://hdl.handle.net/10339/39021"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["bioresorbable conduit"],"dc:title":["REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:39Z"}