{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/37443"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/37443","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"A Complete Dosimetric Model of the Gamma Knife Perfexion Using Penelope Monte Carlo Codes","abstract":"The Gamma Knife Perfexion is a radiosurgical treatment device used to irradiate targets in the head. It uses 192 high-activity Cobalt-60 sources collimated to a common focus to impart radiological damage to the target structure while minimizing dose to adjacent healthy tissue. Tungsten collimators are organized into eight sectors of 24 sources each; each sector can be set to one of three collimation sizes. The collimators can produce nominal spheres of dose 16 mm, 8 mm, or 4 mm in diameter at the focus. Planning for Gamma Knife stereotactic radiosurgery (GK SRS) is performed using images from computed tomography (CT) and/or magnetic resonance (MR) imaging, as well as manual skull measurements. The manufacturer's software used to plan the delivery of these treatments uses a simplistic set of assumptions that do not consider heterogeneous tissue structures.","abstract_html":"The Gamma Knife Perfexion is a radiosurgical treatment device used to irradiate targets in the head. It uses 192 high-activity Cobalt-60 sources collimated to a common focus to impart radiological damage to the target structure while minimizing dose to adjacent healthy tissue. Tungsten collimators are organized into eight sectors of 24 sources each; each sector can be set to one of three collimation sizes. The collimators can produce nominal spheres of dose 16 mm, 8 mm, or 4 mm in diameter at the focus. Planning for Gamma Knife stereotactic radiosurgery (GK SRS) is performed using images from computed tomography (CT) and/or magnetic resonance (MR) imaging, as well as manual skull measurements. The manufacturer's software used to plan the delivery of these treatments uses a simplistic set of assumptions that do not consider heterogeneous tissue structures.","abstract_has_math":false,"creators":["Best, Ryan C. 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It uses 192 high-activity Cobalt-60 sources collimated to a common focus to impart radiological damage to the target structure while minimizing dose to adjacent healthy tissue. Tungsten collimators are organized into eight sectors of 24 sources each; each sector can be set to one of three collimation sizes. The collimators can produce nominal spheres of dose 16 mm, 8 mm, or 4 mm in diameter at the focus. Planning for Gamma Knife stereotactic radiosurgery (GK SRS) is performed using images from computed tomography (CT) and/or magnetic resonance (MR) imaging, as well as manual skull measurements. The manufacturer's software used to plan the delivery of these treatments uses a simplistic set of assumptions that do not consider heterogeneous tissue structures."]},{"key":"dc:title","label":"Title","values":["A Complete Dosimetric Model of the Gamma Knife Perfexion Using Penelope Monte Carlo Codes"]}]}],"canonical_facts":{"dc:creator":["Best, Ryan C. 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The manufacturer's software used to plan the delivery of these treatments uses a simplistic set of assumptions that do not consider heterogeneous tissue structures."],"dc:identifier.uri":["http://hdl.handle.net/10339/37443"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["dose distribution"],"dc:title":["A Complete Dosimetric Model of the Gamma Knife Perfexion Using Penelope Monte Carlo Codes"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:27Z"}