{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/37301"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/37301","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Role of the Baroreflex in Long-Term Blood Pressure Regulation in Children Born With Very Low Birth Weight","abstract":"<bold>INTRODUCTION:</bold> Children born preterm and with very low birth weight are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a long-term basis, but evidence is lacking in humans, particularly children. <bold>PURPOSE:</bold> To examine relationships between short-term measures of baroreflex function (i.e. BRS) and long-term ambulatory BP and variability in a cohort of children born with very low birth weight. <bold>METHODS:</bold> Spontaneous BRS was measured during 10 minutes of supine rest using a Continuous Non-Invasive Arterial Pressure (CNAP) Monitor 500. Nevrokard software calculated BRS using the sequence method (BRSseq) and spectral method (LF&alpha;). Ambulatory BP monitoring took place over a 24-hour period. Data were analyzed separately for awake and asleep periods. Variability was calculated as standard deviations (SD) for awake and asleep and a weighted SD for the 24-hour period. Relationships between measures of BRS and ambulatory BP were examined using correlational analysis. <bold>RESULTS:</bold> A total of 33 participants (22 female, 11 male) had both BRS and ambulatory BP data. Mean BRS values were 24.2 ± 20.4 ms*mmHg-1 for BRSseq and 23.3 ± 12.7 ms*mmHg-1 for LF&alpha;. Mean absolute ambulatory SBP/DBP for the 24-hour period was 115.4/66.9. Mean ambulatory BP variability was 9.1 ± 17 mmHg for the 24-hour period. Negative correlations were found between BRSseq and both 24-hour SBP (r=-.336, p=.087) and asleep SBP (r=-.370, p=.053). There were no significant relationships between BRS and ambulatory BP variability. <bold>CONCLUSION:</bold> The results revealed that BRS accounted for 11-14% of the shared variance in ambulatory SBP suggesting that the baroreflex likely plays at least a partial role in regulating BP on a long-term basis in preterm, VLBW adolescents who are at risk for developing hypertension.","abstract_html":"&lt;bold&gt;INTRODUCTION:&lt;/bold&gt; Children born preterm and with very low birth weight are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a long-term basis, but evidence is lacking in humans, particularly children. &lt;bold&gt;PURPOSE:&lt;/bold&gt; To examine relationships between short-term measures of baroreflex function (i.e. BRS) and long-term ambulatory BP and variability in a cohort of children born with very low birth weight. &lt;bold&gt;METHODS:&lt;/bold&gt; Spontaneous BRS was measured during 10 minutes of supine rest using a Continuous Non-Invasive Arterial Pressure (CNAP) Monitor 500. Nevrokard software calculated BRS using the sequence method (BRSseq) and spectral method (LF&amp;alpha;). Ambulatory BP monitoring took place over a 24-hour period. Data were analyzed separately for awake and asleep periods. Variability was calculated as standard deviations (SD) for awake and asleep and a weighted SD for the 24-hour period. Relationships between measures of BRS and ambulatory BP were examined using correlational analysis. &lt;bold&gt;RESULTS:&lt;/bold&gt; A total of 33 participants (22 female, 11 male) had both BRS and ambulatory BP data. Mean BRS values were 24.2 ± 20.4 ms*mmHg-1 for BRSseq and 23.3 ± 12.7 ms*mmHg-1 for LF&amp;alpha;. Mean absolute ambulatory SBP/DBP for the 24-hour period was 115.4/66.9. Mean ambulatory BP variability was 9.1 ± 17 mmHg for the 24-hour period. Negative correlations were found between BRSseq and both 24-hour SBP (r=-.336, p=.087) and asleep SBP (r=-.370, p=.053). There were no significant relationships between BRS and ambulatory BP variability. &lt;bold&gt;CONCLUSION:&lt;/bold&gt; The results revealed that BRS accounted for 11-14% of the shared variance in ambulatory SBP suggesting that the baroreflex likely plays at least a partial role in regulating BP on a long-term basis in preterm, VLBW adolescents who are at risk for developing hypertension.","abstract_has_math":false,"creators":["Mazanka, Paul James"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-27T22:01:27Z","subjects":["baroreceptors"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/37301","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mazanka, Paul James"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-06-12T08:36:04Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["baroreceptors"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/37301"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["<bold>INTRODUCTION:</bold> Children born preterm and with very low birth weight are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a long-term basis, but evidence is lacking in humans, particularly children. <bold>PURPOSE:</bold> To examine relationships between short-term measures of baroreflex function (i.e. BRS) and long-term ambulatory BP and variability in a cohort of children born with very low birth weight. <bold>METHODS:</bold> Spontaneous BRS was measured during 10 minutes of supine rest using a Continuous Non-Invasive Arterial Pressure (CNAP) Monitor 500. Nevrokard software calculated BRS using the sequence method (BRSseq) and spectral method (LF&alpha;). Ambulatory BP monitoring took place over a 24-hour period. Data were analyzed separately for awake and asleep periods. Variability was calculated as standard deviations (SD) for awake and asleep and a weighted SD for the 24-hour period. Relationships between measures of BRS and ambulatory BP were examined using correlational analysis. <bold>RESULTS:</bold> A total of 33 participants (22 female, 11 male) had both BRS and ambulatory BP data. Mean BRS values were 24.2 ± 20.4 ms*mmHg-1 for BRSseq and 23.3 ± 12.7 ms*mmHg-1 for LF&alpha;. Mean absolute ambulatory SBP/DBP for the 24-hour period was 115.4/66.9. Mean ambulatory BP variability was 9.1 ± 17 mmHg for the 24-hour period. Negative correlations were found between BRSseq and both 24-hour SBP (r=-.336, p=.087) and asleep SBP (r=-.370, p=.053). There were no significant relationships between BRS and ambulatory BP variability. <bold>CONCLUSION:</bold> The results revealed that BRS accounted for 11-14% of the shared variance in ambulatory SBP suggesting that the baroreflex likely plays at least a partial role in regulating BP on a long-term basis in preterm, VLBW adolescents who are at risk for developing hypertension."]},{"key":"dc:title","label":"Title","values":["Role of the Baroreflex in Long-Term Blood Pressure Regulation in Children Born With Very Low Birth Weight"]}]}],"canonical_facts":{"dc:creator":["Mazanka, Paul James"],"dc:date.accessioned":["2012-06-12T08:36:04Z"],"dc:date.issued":["2012"],"dc:description.abstract":["<bold>INTRODUCTION:</bold> Children born preterm and with very low birth weight are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a long-term basis, but evidence is lacking in humans, particularly children. <bold>PURPOSE:</bold> To examine relationships between short-term measures of baroreflex function (i.e. BRS) and long-term ambulatory BP and variability in a cohort of children born with very low birth weight. <bold>METHODS:</bold> Spontaneous BRS was measured during 10 minutes of supine rest using a Continuous Non-Invasive Arterial Pressure (CNAP) Monitor 500. Nevrokard software calculated BRS using the sequence method (BRSseq) and spectral method (LF&alpha;). Ambulatory BP monitoring took place over a 24-hour period. Data were analyzed separately for awake and asleep periods. Variability was calculated as standard deviations (SD) for awake and asleep and a weighted SD for the 24-hour period. Relationships between measures of BRS and ambulatory BP were examined using correlational analysis. <bold>RESULTS:</bold> A total of 33 participants (22 female, 11 male) had both BRS and ambulatory BP data. Mean BRS values were 24.2 ± 20.4 ms*mmHg-1 for BRSseq and 23.3 ± 12.7 ms*mmHg-1 for LF&alpha;. Mean absolute ambulatory SBP/DBP for the 24-hour period was 115.4/66.9. Mean ambulatory BP variability was 9.1 ± 17 mmHg for the 24-hour period. Negative correlations were found between BRSseq and both 24-hour SBP (r=-.336, p=.087) and asleep SBP (r=-.370, p=.053). There were no significant relationships between BRS and ambulatory BP variability. <bold>CONCLUSION:</bold> The results revealed that BRS accounted for 11-14% of the shared variance in ambulatory SBP suggesting that the baroreflex likely plays at least a partial role in regulating BP on a long-term basis in preterm, VLBW adolescents who are at risk for developing hypertension."],"dc:identifier.uri":["http://hdl.handle.net/10339/37301"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["baroreceptors"],"dc:title":["Role of the Baroreflex in Long-Term Blood Pressure Regulation in Children Born With Very Low Birth Weight"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:01:27Z"}