Acyloxy Nitroso Compounds as HNO Donors and Their Reactions with Thiol and Heme Containing Proteins

Nitroxyl (HNO), a nitrogen monoxide with distinct chemistry and biology, has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during decomposition limits the use of AS requiring other HNO sources. Acyloxy nitroso compounds hydrolyze to HNO, while the rate of decomposition of these compounds can change through variation of the ester portion of the molecule. A number of cyclohexanone acyloxy nitroso compounds that contain different R groups on the ester that include a t-butyl group to increase stability, long side chains and double bonds to increase lipophilicity, and oxygen in the ring to increase solubility , were synthesized and characterized as HNO donors.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2012

Author dc:creator

• DuMond, Jenna F.

• Aldehyde Dehydrogenase (ALDH)

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/37271

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/37271