{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/36445"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/36445","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury","abstract":"Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly with limbic regions involved in reward and reinforcement, therefore pain and reward systems substantially interact and modulate one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown.","abstract_html":"Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly with limbic regions involved in reward and reinforcement, therefore pain and reward systems substantially interact and modulate one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown.","abstract_has_math":false,"creators":["Ewan, Eric Edward"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/36445","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ewan, Eric Edward"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-01-18T09:35:36Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-07-18T08:30:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/36445"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly with limbic regions involved in reward and reinforcement, therefore pain and reward systems substantially interact and modulate one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown."]},{"key":"dc:title","label":"Title","values":["Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury"]}]}],"canonical_facts":{"dc:creator":["Ewan, Eric Edward"],"dc:date.accessioned":["2012-01-18T09:35:36Z"],"dc:date.available":["2012-07-18T08:30:16Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly with limbic regions involved in reward and reinforcement, therefore pain and reward systems substantially interact and modulate one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown."],"dc:identifier.uri":["http://hdl.handle.net/10339/36445"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:title":["Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}