{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/36443"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/36443","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE","abstract":"Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic infection. GAS has evolved the ability to colonize a variety of distinct host sites, and one possible mechanism for colonization is through the formation of a biofilm. A biofilm is a structured, sessile microbial community encased in an extracellular matrix and may provide protection from the immune response and antibiotic therapy. We and others have shown that GAS is able to form biofilms <italic>in vitro<italic> and <italic>in vivo<italic>, however, the regulation and role of these structures during an infection remains unclear.","abstract_html":"Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic infection. GAS has evolved the ability to colonize a variety of distinct host sites, and one possible mechanism for colonization is through the formation of a biofilm. A biofilm is a structured, sessile microbial community encased in an extracellular matrix and may provide protection from the immune response and antibiotic therapy. We and others have shown that GAS is able to form biofilms &lt;italic&gt;in vitro&lt;italic&gt; and &lt;italic&gt;in vivo&lt;italic&gt;, however, the regulation and role of these structures during an infection remains unclear.","abstract_has_math":false,"creators":["Connolly, Kristie Lee"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":["Biofilms"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/36443","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Connolly, Kristie Lee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-01-18T09:35:35Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-01-18T09:30:11Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biofilms"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/36443"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic infection. GAS has evolved the ability to colonize a variety of distinct host sites, and one possible mechanism for colonization is through the formation of a biofilm. A biofilm is a structured, sessile microbial community encased in an extracellular matrix and may provide protection from the immune response and antibiotic therapy. We and others have shown that GAS is able to form biofilms <italic>in vitro<italic> and <italic>in vivo<italic>, however, the regulation and role of these structures during an infection remains unclear."]},{"key":"dc:title","label":"Title","values":["SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE"]}]}],"canonical_facts":{"dc:creator":["Connolly, Kristie Lee"],"dc:date.accessioned":["2012-01-18T09:35:35Z"],"dc:date.available":["2014-01-18T09:30:11Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic infection. GAS has evolved the ability to colonize a variety of distinct host sites, and one possible mechanism for colonization is through the formation of a biofilm. A biofilm is a structured, sessile microbial community encased in an extracellular matrix and may provide protection from the immune response and antibiotic therapy. We and others have shown that GAS is able to form biofilms <italic>in vitro<italic> and <italic>in vivo<italic>, however, the regulation and role of these structures during an infection remains unclear."],"dc:identifier.uri":["http://hdl.handle.net/10339/36443"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Biofilms"],"dc:title":["SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}