{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/36426"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/36426","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl","abstract":"Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.","abstract_html":"Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.","abstract_has_math":false,"creators":["Reisz, Julie Ann"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":["Angeli's salt"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/36426","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Reisz, Julie Ann"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-01-18T09:35:28Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-01-18T09:30:11Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Angeli's salt"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/36426"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO."]},{"key":"dc:title","label":"Title","values":["Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl"]}]}],"canonical_facts":{"dc:creator":["Reisz, Julie Ann"],"dc:date.accessioned":["2012-01-18T09:35:28Z"],"dc:date.available":["2014-01-18T09:30:11Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO."],"dc:identifier.uri":["http://hdl.handle.net/10339/36426"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Angeli's salt"],"dc:title":["Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}