{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/33501"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/33501","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection","abstract":"Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection.","abstract_html":"Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection.","abstract_has_math":false,"creators":["Beauchamp, Nicole"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":["CD8 T cells"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/33501","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Beauchamp, Nicole"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-07-14T20:36:31Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-07-14T08:30:19Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["CD8 T cells"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/33501"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection."]},{"key":"dc:title","label":"Title","values":["Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection"]}]}],"canonical_facts":{"dc:creator":["Beauchamp, Nicole"],"dc:date.accessioned":["2011-07-14T20:36:31Z"],"dc:date.available":["2012-07-14T08:30:19Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection."],"dc:identifier.uri":["http://hdl.handle.net/10339/33501"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["CD8 T cells"],"dc:title":["Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}