{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/33490"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/33490","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment","abstract":"Ang-(1-7) is an endogenous peptide hormone that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a therapeutic agent. In this study, athymic mice with human LNCaP xenografts were infused with saline or Ang-(1-7) (24 g/kg/h) for 54 days. The heptapeptide markedly reduced tumor volume and wet weight as compared to saline administration. Tumors from mice treated with Ang-(1-7) had a 78% reduction in Ki67 and a 55% decrease in the phosphorylation of the MAP kinases ERK1 and ERK2, compared to tumor tissue from Ang-(1-7)-medicated animals, suggesting that the heptapeptide reduces cell proliferation. A significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 nM Ang-(1-7) in vitro, supporting the anti-proliferative properties of the heptapeptide. Mas was detected by Western blot hybridization in both cell types.","abstract_html":"Ang-(1-7) is an endogenous peptide hormone that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a therapeutic agent. In this study, athymic mice with human LNCaP xenografts were infused with saline or Ang-(1-7) (24 g/kg/h) for 54 days. The heptapeptide markedly reduced tumor volume and wet weight as compared to saline administration. Tumors from mice treated with Ang-(1-7) had a 78% reduction in Ki67 and a 55% decrease in the phosphorylation of the MAP kinases ERK1 and ERK2, compared to tumor tissue from Ang-(1-7)-medicated animals, suggesting that the heptapeptide reduces cell proliferation. A significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 nM Ang-(1-7) in vitro, supporting the anti-proliferative properties of the heptapeptide. Mas was detected by Western blot hybridization in both cell types.","abstract_has_math":false,"creators":["Krishnan, Bhavani"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:20Z","subjects":["Angiogenesis"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/33490","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Krishnan, Bhavani"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-07-14T20:36:20Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Angiogenesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/33490"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Ang-(1-7) is an endogenous peptide hormone that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a therapeutic agent. In this study, athymic mice with human LNCaP xenografts were infused with saline or Ang-(1-7) (24 g/kg/h) for 54 days. The heptapeptide markedly reduced tumor volume and wet weight as compared to saline administration. Tumors from mice treated with Ang-(1-7) had a 78% reduction in Ki67 and a 55% decrease in the phosphorylation of the MAP kinases ERK1 and ERK2, compared to tumor tissue from Ang-(1-7)-medicated animals, suggesting that the heptapeptide reduces cell proliferation. A significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 nM Ang-(1-7) in vitro, supporting the anti-proliferative properties of the heptapeptide. Mas was detected by Western blot hybridization in both cell types."]},{"key":"dc:title","label":"Title","values":["Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment"]}]}],"canonical_facts":{"dc:creator":["Krishnan, Bhavani"],"dc:date.accessioned":["2011-07-14T20:36:20Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Ang-(1-7) is an endogenous peptide hormone that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a therapeutic agent. In this study, athymic mice with human LNCaP xenografts were infused with saline or Ang-(1-7) (24 g/kg/h) for 54 days. The heptapeptide markedly reduced tumor volume and wet weight as compared to saline administration. Tumors from mice treated with Ang-(1-7) had a 78% reduction in Ki67 and a 55% decrease in the phosphorylation of the MAP kinases ERK1 and ERK2, compared to tumor tissue from Ang-(1-7)-medicated animals, suggesting that the heptapeptide reduces cell proliferation. A significant reduction in both LNCaP and PC3 cell growth was observed following incubation with 100 nM Ang-(1-7) in vitro, supporting the anti-proliferative properties of the heptapeptide. Mas was detected by Western blot hybridization in both cell types."],"dc:identifier.uri":["http://hdl.handle.net/10339/33490"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Angiogenesis"],"dc:title":["Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:20Z"}