{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/33459"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/33459","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS","abstract":"Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids.","abstract_html":"Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids.","abstract_has_math":false,"creators":["Brown, Amanda Lynn"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:14Z","subjects":["alternative"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/33459","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Brown, Amanda Lynn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-07-14T20:35:38Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-07-14T08:30:17Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["alternative"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/33459"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids."]},{"key":"dc:title","label":"Title","values":["THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS"]}]}],"canonical_facts":{"dc:creator":["Brown, Amanda Lynn"],"dc:date.accessioned":["2011-07-14T20:35:38Z"],"dc:date.available":["2012-07-14T08:30:17Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids."],"dc:identifier.uri":["http://hdl.handle.net/10339/33459"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["alternative"],"dc:title":["THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:14Z"}