SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES

This project delves into the mechanistic details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient under hypoxic conditions such as that in cancer cells. Development and optimization of a water soluble caged anthraquinone that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in the process, are investigated.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2011

Author dc:creator

• SARMA, SAURAV JYOTI

• caged-anthraquinone

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/33419

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/33419