{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/33416"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/33416","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION","abstract":"Age is the single most important determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a significant impairment in neuromuscular recovery after peripheral nerve injury and repair. There was a significant impairment in the response of the neuromuscular junction (NMJ) to peripheral nerve injury. Using a dwarf rat model of GH-deficiency, it was found that a lack of circulating GH does not lead to impairments in neuromuscular recovery after nerve injury. Replenishment of GH in aged or GH-deficient rats does not affect neuromuscular recovery. Lastly, it was found that IGF-1, locally-delivered to the site of the regenerating nerve, improved neuromuscular recovery after injury in aged rats. Overall, these results emphasize the role of the NMJ in age-related decline in neuromuscular recovery after peripheral nerve injury and suggest that alterations in local regenerative mechanisms are more important than changes in the systemic GH-IGF-1 axis.","abstract_html":"Age is the single most important determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a significant impairment in neuromuscular recovery after peripheral nerve injury and repair. There was a significant impairment in the response of the neuromuscular junction (NMJ) to peripheral nerve injury. Using a dwarf rat model of GH-deficiency, it was found that a lack of circulating GH does not lead to impairments in neuromuscular recovery after nerve injury. Replenishment of GH in aged or GH-deficient rats does not affect neuromuscular recovery. Lastly, it was found that IGF-1, locally-delivered to the site of the regenerating nerve, improved neuromuscular recovery after injury in aged rats. Overall, these results emphasize the role of the NMJ in age-related decline in neuromuscular recovery after peripheral nerve injury and suggest that alterations in local regenerative mechanisms are more important than changes in the systemic GH-IGF-1 axis.","abstract_has_math":false,"creators":["Apel, Peter J."],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-27T22:01:14Z","subjects":["Aging"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/33416","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Apel, Peter J."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-07-14T20:34:48Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-07-14T20:34:48Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/33416"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Age is the single most important determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a significant impairment in neuromuscular recovery after peripheral nerve injury and repair. There was a significant impairment in the response of the neuromuscular junction (NMJ) to peripheral nerve injury. Using a dwarf rat model of GH-deficiency, it was found that a lack of circulating GH does not lead to impairments in neuromuscular recovery after nerve injury. Replenishment of GH in aged or GH-deficient rats does not affect neuromuscular recovery. Lastly, it was found that IGF-1, locally-delivered to the site of the regenerating nerve, improved neuromuscular recovery after injury in aged rats. Overall, these results emphasize the role of the NMJ in age-related decline in neuromuscular recovery after peripheral nerve injury and suggest that alterations in local regenerative mechanisms are more important than changes in the systemic GH-IGF-1 axis."]},{"key":"dc:title","label":"Title","values":["THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION"]}]}],"canonical_facts":{"dc:creator":["Apel, Peter J."],"dc:date.accessioned":["2011-07-14T20:34:48Z"],"dc:date.available":["2011-07-14T20:34:48Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Age is the single most important determinant of recovery after peripheral nerve injury. With aging, there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a significant impairment in neuromuscular recovery after peripheral nerve injury and repair. There was a significant impairment in the response of the neuromuscular junction (NMJ) to peripheral nerve injury. Using a dwarf rat model of GH-deficiency, it was found that a lack of circulating GH does not lead to impairments in neuromuscular recovery after nerve injury. Replenishment of GH in aged or GH-deficient rats does not affect neuromuscular recovery. Lastly, it was found that IGF-1, locally-delivered to the site of the regenerating nerve, improved neuromuscular recovery after injury in aged rats. Overall, these results emphasize the role of the NMJ in age-related decline in neuromuscular recovery after peripheral nerve injury and suggest that alterations in local regenerative mechanisms are more important than changes in the systemic GH-IGF-1 axis."],"dc:identifier.uri":["http://hdl.handle.net/10339/33416"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Aging"],"dc:title":["THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:14Z"}