{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/30422"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/30422","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE","abstract":"Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly individuals and to understand the neurobiology of aging. The present studies were designed to assess the effects of aging on cognitive abilities dependent on hippocampal/mediotemporal lobe and frontostriatal function, brain regions involved in memory and behavioral flexibility, respectively, and to investigate potential factors associated with cognitive decline.","abstract_html":"Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly individuals and to understand the neurobiology of aging. The present studies were designed to assess the effects of aging on cognitive abilities dependent on hippocampal/mediotemporal lobe and frontostriatal function, brain regions involved in memory and behavioral flexibility, respectively, and to investigate potential factors associated with cognitive decline.","abstract_has_math":false,"creators":["Nieves-Martinez, Erasmo"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-27T22:01:14Z","subjects":["aging"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/30422","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Nieves-Martinez, Erasmo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-02-16T21:42:33Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-02-16T21:42:33Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["aging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/30422"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly individuals and to understand the neurobiology of aging. The present studies were designed to assess the effects of aging on cognitive abilities dependent on hippocampal/mediotemporal lobe and frontostriatal function, brain regions involved in memory and behavioral flexibility, respectively, and to investigate potential factors associated with cognitive decline."]},{"key":"dc:title","label":"Title","values":["COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE"]}]}],"canonical_facts":{"dc:creator":["Nieves-Martinez, Erasmo"],"dc:date.accessioned":["2011-02-16T21:42:33Z"],"dc:date.available":["2011-02-16T21:42:33Z"],"dc:date.issued":["2010"],"dc:description.abstract":["Normal aging can result in cognitive decline even in the absence of neurodegenerative disease. Successful identification of neurobiological changes that occur in association with age-related cognitive decline is needed to develop strategies to restore or preserve cognitive function in elderly individuals and to understand the neurobiology of aging. The present studies were designed to assess the effects of aging on cognitive abilities dependent on hippocampal/mediotemporal lobe and frontostriatal function, brain regions involved in memory and behavioral flexibility, respectively, and to investigate potential factors associated with cognitive decline."],"dc:identifier.uri":["http://hdl.handle.net/10339/30422"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["aging"],"dc:title":["COGNITIVE DECLINE WITH AGE: ROLE OF STRIATAL CHOLINERGIC SYSTEM AND GROWTH HORMONE"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:14Z"}